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Topamac (Topiramate)
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Topiramate

Topamac is used alone or together with other medicines to help treat certain types of seizures (eg, partial seizures, tonic-clonic seizures, or Lennox-Gastaut syndrome). This medicine will not cure epilepsy and will only work to control seizures for as long as you continue to take it. It is also used to help prevent migraine headaches. This medicine is available only with your doctor's prescription.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Topamac comes as a tablet, a sprinkle capsule (capsule that contains small beads of medication that can be sprinkled on food), and an extended-release (long-acting) capsule to take by mouth. The tablets and sprinkle capsules are usually taken with or without food once or twice a day. The extended-release capsules are usually taken with or without food once a day. Take Topamac at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Topamac exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

There is another medication with a name similar to the brand name for Topamac. You should be sure that you receive Topamac and not the similar medication each time you fill your prescription. Be sure that the prescription your doctor gives you is clear and easy to read. Talk to your pharmacist to be sure that you are given Topamac. If you think you were given the wrong medication, talk to your pharmacist. Do not take any medication unless you are certain it is the medication that your doctor prescribed.

Topamac tablets have a bitter taste so you should swallow them whole. It is especially important that you not take Topamac tablets that have been broken for any length of time because tablets that are broken may lose their effectiveness over time.

The sprinkle and extended-release capsules (Qudexy XR brand only) may be swallowed whole or opened and poured over soft food. Swallow extended-release capsules (Trokendi XR brand only) whole; do not split, chew, or sprinkle on food.

To take the sprinkle capsules or extended-release capsules (Qudexy XR brand only) with food, follow these steps:

  1. Prepare a teaspoonful of soft food such as applesauce, custard, ice cream, oatmeal, pudding, or yogurt.
  2. Hold the capsule upright over the food.
  3. Twist off the top of the capsule and pour the entire contents onto the spoonful of food.
  4. Swallow the entire mixture immediately without chewing.
  5. Drink fluids right after swallowing to wash down the mixture and to be sure that you swallow all of it.

Your doctor will probably start you on a low dose of Topamac and gradually increase your dose, not more than once every week.

Topamac may control your seizures or migraines but will not cure your condition. Continue to take Topamac even if you feel well. Do not stop taking Topamac without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. If you suddenly stop taking Topamac, you may have severe seizures, even if you have not had seizures in the past. Your doctor will probably decrease your dose gradually.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with Topamac and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide.

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The absence of interspecific variations proves that Lanistes snails in Egypt belong to one species. The models were used to teach normal physical examination skills to a group of junior medical students, during their surgical rotation. We also determined that a close approximation of Pdo may be derived from the raw data, as an alternative to exponential curve fitting.

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However, when these etioplast membranes are supplemented with the chlorophyll analogs Zn-pheophytin a/b, synthesized in situ from Zn-pheophorbide a/b and digeranyl pyrophosphate, pLHCP is inserted into a protease-resistant state. The correlations of LAPTM4B-35 expression with clinicopathological parameters, including gender, age, background liver, viral status, tumor size, portal vein invasion, histopathological differentiation, serum AFP level, TNM staging and recurrence of HCC were assessed by Chi-squared test. In conclusion, wearing a nose-clip during EBC collection is not recommended in terms of convenience and compliance for repeated investigations. Maternal conditions, fetal or obstetrical predisposing risk factors have been proposed to have a causative role, but the pathogenesis of fetal gallstones remains unknown. The Japanese Histologic Classification and T-score in the Oxford Classification system could predict renal outcome in Japanese IgA nephropathy patients.

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Recently, using surface imaging techniques such as field emission in-lens scanning electron microscopy, novel structures have been identified, particularly at the periphery of the structure, most notably the nucleoplasmic basket. We found that amphiregulin (AR) was the most abundant EGFR ligand expressed in HCA-7 and Caco-2 cells. Laparotomy revealed a free purulent fluid around second portion of the duodenum caused by perforation of a duodenal diverticulum. The results of the measurements were corrected to a sound pressure in the external ear canal.

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This study provides the first demonstration that multi-sensory distraction has powerful effects on selective attention: Adults and older children alike allocate attention to potentially relevant information across multiple senses. We show that beta(2)m is important for cell surface expression of FcRn and that, in the absence of beta(2)m, the receptor is retained in the endoplasmic reticulum.

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Using small molecules as a new challenge to redirect metabolic pathway. Due to the continued use of broad-spectrum oral and systemic antimicrobials to treat ocular infections, findings of this study and other surveillance studies specific to ocular isolates should be used as resources in effective decision making in the treatment of ocular disease. Links between electroencephalograms (EEGs) and underlying aspects of neurophysiology and anatomy are poorly understood. The possibility of correcting defective genes and modulating gene expression through gene therapy has emerged as a promising treatment strategy for breast cancer.

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The width of the cervical prevertebral shadow was compared in two groups of patients--24 with definite traumatic lesions and 66 with no history of trauma. The results also indicate that in HPA-1a negative women the absence of HLA-DRw52a is associated with a very low risk of being antibody producers and hence, is associated with a very low risk for NAITP in their new-borns. The diagnosis of cysticercosis in unusual sites such as breast may be clinically difficult and this supports why all biopsies must be sent to the pathologists for definitive diagnosis. We found that proteolytic activation of pro-MMP-9 was mediated by a tissue-associated chymotrypsin-like proteinase, designated here as pro-MMP-9 activator (pM9A). However, not all of them would be convincing even with testing of a large number of cases.

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Cadmium (Cd), lead (Pb), copper (Cu) and zinc (Zn) levels in khat and 6 leafy vegetables commonly consumed in the Republic of Yemen were determined by differential pulse anodic stripping voltammetry after wet digestion of the organic matter. This improvement is small and is usually not sufficient to reach lipid target levels. Neurobiology, Screening, and Epidemiology were the most widely viewed modules. These results correspond with the known crossreactivity of antibody against S.

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Pathways from symptoms to medical care: a descriptive study of symptom development and obstacles to early diagnosis in brain tumour patients. We focus on the time sequence and ultrastructural features of angiogenesis, hypoxia as a trigger, role of vascular endothelial growth factor signaling (VEGF), serum response factor, Cox2 and prostaglandins, nitric oxide, and importin. The relationship of urinary metabolites of carbaryl/naphthalene and chlorpyrifos with human semen quality.

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Whole human and animal blood was found to be capable of inducing chromosome aberrations far exceeding the level of spontaneous mutations. 43,738 men 40 to 75 years of age who did not have cardiovascular disease or diabetes. Amyloidosis: rapid course of AL-amyloidosis in a patient without myelomatosis The relationship of transmitter release and storage to fine structure in a sympathetic ganglion. As a result of experiments carried out on adult (6-8 months) and old (24-26 months) male rats of the Wistar line it is established that emotional-pain stress results (in one day) in essential increase in the activity of spontaneous, NADPH--and ascorbate-dependent peroxidation of lipids in the liver microsomes, which is expressed in the old animals rather than in the adult ones.

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The presence of preoperative extraintestinal manifestations was found to be an independent risk factor for the development of overall and chronic pouchitis. The use of luteal phase support in stimulated cycles has been associated with higher live-birth rates and the results are similar when using hCG or progesterone.

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In the smelting industry airborne pollutants are emitted into the workplace atmosphere during the production process. Our findings support the future conduct of larger clinical trials to confirm the safety and efficacy of rotavirus vaccination in the neonatal period.

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We estimated the proportion of HIV-negative MSM testing repeatedly at 12-month or smaller intervals at a large STI clinic in the Netherlands. The remaining one-third of the data were used to validate several sparse sampling designs.

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Furthermore, adjuvanticity of CT was unaffected in IL-12-deficient mice, while OVA-ISCOM showed partly impaired adjuvant effects by the lack of IL-12. The response of mat diatoms to disturbance varied markedly during the experiment, from strong reductions in the abundance of loosely attached mats in mid-late 2000 to the exploitation of open space by closely adhering mats in 2001.

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Increases in blood pressure and heart rate are possible adverse effects that require regular monitoring. The LTD induced by glucocorticoid receptor activation was dependent on N-methyl-D-aspartate (NMDA) receptor activity, because the specific NMDA receptor antagonist D(-)-2-amino-5-phosphonopentanoic acid (D-AP5) blocked the facilitation.

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Clinicians need to be cautious when interpreting questionnaires and be aware of the possibility of nonspecific symptom endorsement, symptom overendorsement, symptom expectations influencing symptom endorsement, and the nocebo effect. Eight adult female patients suffering from abdominal pain and chronic diarrhea which was often incapacitating and frequently nocturnal, had dramatic relief on a gluten-free diet and return of symptoms after gluten challenge. These mechanisms can affect the stability of both the native state and the unfolded state. Furthermore, all patients have remained well on an outpatient basis.

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Psychometric validation of the State Scale of Dissociation (SSD). Historical view of the influences of measurement and reading theories on the assessment of reading. We used a combination of confocal immunofluorescence microscopy, flow cytometry, and secretion assays, including beta-hexosaminidase, eosinophil peroxidase, and RANTES, to examine CD63 expression, intracellular localization, and its association with cell activation and mediator release. Evaluation of the morphology of stapedial reflex in otosclerosis. Ka/Ks analysis and likelihood ratio tests showed considerably higher Ka values and Ka/Ks ratios in numit rps13 than in nucp rps13, indicating increased amino acid sequence divergence in numit rps13.

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The phage shock protein (Psp) system found in enterobacteria is induced in response to impaired inner membrane integrity (where the Psp response is thought to help maintain the proton motive force of the cell) and is implicated in the virulence of pathogens such as Yersinia and Salmonella. Peripheral blood T lymphocytes of seven asthma patients were stimulated with anti-CD3 plus anti-CD28 MoAbs in the absence and presence of isoproterenol (ISO) and prostaglandin E2 (PGE2) to activate the AC system. Further improvement in assay development is needed to utilize this type of assay in identification of ideal patient population for this therapy. Notable effects on the plaque size of other factors such as the procedure for sterilization of the agar medium, the volume and softness of the top and bottom layers, and the number and growth stage of the bacterial cells added to the lawn, were also observed. Italian policies should make an effort to increase transplant rates to optimize cost-effectiveness in ESRD service supply.

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Blunt chest trauma can produce a number of potentially lethal injuries, including pulmonary artery rupture. Arguments for testing ethnic identity and acculturation as factors in risk judgments. The anterolateral complex in anterior cruciate ligament deficient knees demonstrate sonographic abnormalities on high-resolution sonography. Diagonal Earlobe Crease as a Significant Marker for Coronary Artery Disease: A Case-control Study.

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The Friberg microagglutination tray technique for the detection of sperm-agglutinating antibodies in the serum has several advantages over other techniques. Oocysts are nearly spherical, 103-178 x 103-172 microm, form usually elongate sporocysts, 30-39 x 20-25 microm L/W ratio 1.33-1.94 that contain 16-36 sporozoites. Renal transplantation in hypophosphatemia with vitamin D-resistant rickets. Namely, MEPEs assembled from the electron-rich OMe group modified ligands exhibit high switching reversibility and stability and show a lower switching potential than the unsubstituted and electron-deficient Br-substituted analogues.

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PCMR strain values were compared to values computed independently from contours drawn on cine steady-state free procession (SSFP) images. To assess how well screening and preventive measures are implemented in the general population. The purpose of the present investigation was to study the systemic inflammatory and stress responses and the innate response mediated by neutrophils in OA patients. In addition, tissue-specific transcription factors have been linked to the coordinate synthesis of contractile proteins and muscle-specific respiratory subunits whereas other more ubiquitous factors may have a dual function in nuclear and mitochondrial gene activation. Mutations in conserved residues in the LisH motif of TBL1 and TBLR1 block histone binding, oligomerization, and transcriptional repression, supporting the functional importance of the LisH motif in transcriptional repression.

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We performed a retrospective analysis of the American College of Surgeons National Surgical Quality Improvement Program adult and pediatric databases to produce two cohorts that underwent gynecomastia surgical repair. This interplay depends sensitively on the crystallographic planes, and consequently leads to the anisotropic charge and spin transport in quantum wires embedded in different crystallographic planes. Microbial inoculants are promising components of such management systems. The data indicate that retinoids can potently reduce cyclin D expression levels in a variety of breast cell lines in vitro, and suggest further consideration of this mechanism for the chemoprevention of breast cancer. The circadian rhythm of body temperature (T(b)) is a well-known phenomenon.

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It was found that a significant relationship existed between moral sensitivity and systematic nursing clinical supervision. We developed a personal exposure model using volatile organic compound data collected for teachers and office workers as part of the Boston Exposure Assessment in Microenvironments (BEAM) study.

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One of the possible associated endocrinopathies in APS is hypoparathyroidism. The aim of this study was to better understand the temporal activity of these enzymes during normal wound repair. Plasmonic optical tweezers can overcome the diffraction limits of conventional optical tweezers and enable the trapping of nanoscale objects. The primary outcomes were in-hospital mortality and graft patency. It was found that the process of perception and assimilation of educational information in foreign languages is associated with some degree of mental and emotional stress of students.

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Structure of artificial cytoskeleton containing liposomes in aqueous solution studied by static and dynamic light scattering. If the conditional probability density function for the measurements is known, then detection can be achieved by sampling the parameter space at a finite number of points and checking each point to see if the corresponding structure is supported by the data. Archival data for 68 veterans was drawn from electronic medical records for which compensation-seeking status was available. This will require an improved understanding of how to harness their biological potency for regenerative therapies that are specifically targeted to the oral mucosa. In blood anticoagulated with low molecular mass heparin, platelet aggregation to collagen tended to be enhanced as compared to hirudin treated blood, whereas platelet responses to ADP at a high concentration were slightly reduced.

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To better understand the MR imaging features of HCC, recent progress regarding its etiology, treatment, carcinogenesis, histology, and gross pathology will be described. A 16-year-old man who presented with delayed bleeding of epidural hematoma is reported.

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This work extends the existing knowledge of the structure of porphyrans. In untreated patients, nuclear translocation of NF-kappaB was detectable in virtually all macrophages.

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Rift Valley fever outbreak with East-Central African virus lineage in Mauritania, 2003. Based on interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha levels in effusions, our goals were to specify either recurrent or persistent otitis media with effusion (OME) is a mid stage in the development of chronic disease and to identify the factors that have an influence on cytokine levels. Recent studies have also defined relationships between genetic abnormalities and leukemia cell phenotype and drug resistance that may assist in assessing prognosis or assigning therapy. palumbes, and a revised diagnosis of Calliobothrium is presented.

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Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. This study utilizes molecular markers to examine the evolutionary history and microstructural organization of the supernumerary paternal-sex-ratio (PSR) chromosome of the parasitic wasp Nasonia vitripennis. Of the 174 countries for which data on school-based immunization were available, ninety five countries reported using a school-based approach for immunization. Thyroid hormones (THs) play an important role in the normal development and physiological functions in fish.

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With the advent of multidrug-resistant Mycobacterium tuberculosis, new effective drugs are rapidly needed. Altogether, these findings suggest that the up-regulation of CXCR4 by imatinib promotes migration of CML cells to bone marrow stroma, causing the G0-G1 cell cycle arrest and hence ensuring the survival of quiescent CML progenitor cells. The impaired evacuation from the stomach stump was observed in 69 of 331 patients subjected to resection of the stomach for gastro-duodenal ulcer.

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Therefore, many more, and better designed, studies will have to be conducted before the full clinical impact of immunosenescence can be delineated. At 3, 24, 48 or 96 h after administration, the carotenoporphyrin fluorescence was measured in tumoral and peritumoral tissue, as well as omeprazole dosage 40 mg twice a day in the abdominal, thoracic and cranial cavities. The number of virus genome equivalents increased in the hybrid cells after induction of virus with iododeoxyuridine. Asthma is the chronic inflammation of airways characterized by eosinophilic infiltration, mucus overproduction, airway hyper-responsiveness and airway remodeling. The computed tomography-cisternography (CTC) is an important additional investigation with only minimal risks to the patient.

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The aim of this study was to investigate the relationship between zolpidem use and the risk of acute pancreatitis in Taiwan. However, the ectiban 10 mg efectos especiales mechanism by which TNF induces desumoylation of HIPK1 is unclear. Diffusion tensor and functional MR imaging of severe traumatic craniocerebral injury at low magnetic field

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Extensive gene expression analysis in livers of WT and IFNAR-1(-/-) mice revealed a large deficiency in the response to TNF in the calan 240 mg sr knockout mice, especially of IFN-stimulated response element-dependent genes, many of which encode chemokines. The cell line KG-1 has been used as an in vitro model for human dendritic cell (DC) differentiation. Subcutaneous injection of 5-HT1A and beta-adrenergic receptor antagonist (-)-pindolol alone, at 10 mg/kg, had no effect on the extracellular levels of NA or 5-HT. The use of suramin, a strong polyanonic molecule which has been reported to trap growth factors, induces a high reduction of the indirect activation.

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Spatial-time cluster analysis of peptac liquid aniseed spices distribution of schistosomiasis in Jiangling County The metalization of silver on the gold nanoparticles induced a significant color change from red to yellow until black depending on the concentration of the target DNA, which could be recognized by naked eyes.

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Tuberculosis in renal transplant recipients: challenges in developing countries. The effects of the posterior-pituitary peptides oxytocin (OT), arginine-vasopressin (AVP) and lysine-vasopressin (LVP) on insulin and glucagon secretion were examined in adult sheep. Although women make up an increasing percentage of the physician work force in Canada, they still face challenges as they continue to take sinvacor 28cpr riv 20 mg adderall primary responsibility for child care and domestic activities.

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On the formation of new reverse micelles: a comparative study of benzene/surfactants/ionic liquids systems using UV-visible absorption spectroscopy and dynamic light scattering. The authors supplement their 1975 paper on the latest views on osteoclasis with further research on the subject. These experiments support the involvement in metastasis of the pathways identified in invasive cells, which are regulated by ZBP1. Given its apix photography blog name growing usage in clinical medicine for biomarker discovery to predict, diagnose and confer prognosis, MS-based proteomics can benefit study of personalized medicine.