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This work describes two contributions to the field of gene regulation in the undifferentiated intestine--first, the initial characterization of a putative mdr1a enhancer region with specificity for primitive intestinal cells and secondly, the first report of mdr1b detection in the intestine and its expression in primitive cell types. Endoscopic surgery also enables the surgeon to make a precise pathological diagnosis.

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A meiotically reproducible chromosome length polymorphism in the ascomycete fungus Ophiostoma ulmi (sensu lato). Some of the adverse effects of class I antiarrhythmic drugs are directly linked to sodium-channel blockade (conduction disorders haemodynamic perturbations, and digestive and neurological effects), while others are linked to other specific pharmacological properties (e.g.

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The sample consisted of 8 undergraduate and graduate nursing students. The absorbance and first-, second- and third-order derivative UV spectroscopic methods were applied for the determination of benazepril hydrochloride (BEN) in model solutions and tablets, as well as the estimation of its stability in solid phase. The description of this morphological diversity observed with light, scanning and transmission electron microscopy is a prerequisite to functional analyses of the symbioses. Anomalous ligand binding by a class of high spin c-type cytochromes.

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A scoring system to predict breast cancer mortality at 5 and 10 years. With the aim of improving hybridization by decreasing electrostatic repulsions between the negatively charged strands, novel modified oligonucleotides named Zip nucleic acids (ZNAs) were recently developed. The object of study was the patients with pesticide poisoning who were first visit to a doctor (including transfer to the above emergency departments of hospitals) from July 1, 2001 to June 30, 2002.

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In both adult and young subjects there was a significant correlation between blood pressure and pain sensitivity: hypertensives had a higher threshold for sensation of pain in the tooth-pulp test than normotensive controls. TGF-beta1 suppressed the slit diaphragm-associated protein P-cadherin, zonula occludens-1, and nephrin, a change consistent with loss of the epithelial feature. To address this question, we replaced the methylated RGG tripeptides of two hnRNPs, Npl3p and Hrp1p, with KGG. C60 fullerene as synergistic agent in tumor-inhibitory Doxorubicin treatment.

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Perpendicular axes of differentiation generated by mitochondrial introgression. Measurement of the characteristics and severity of depression in adolescence is an emerging science. Wnt signaling activates the canonical pathway and induces the accumulation of non-phosphorylated beta-catenin (NPBC) in the nucleus.

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Survival ratio for a given treatment/line was defined as the ratio of median survival for treatment vs. Renal cell carcinomas are typically solitary and aggressive tumors displaying papillary type 2 or collecting duct histology.

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Viability of dried filaments, survivability and reproduction under water stress, and survivability following heat and UV exposure in Lyngbya martensiana, Oscillatoria agardhii, Nostoc calcicola, Hormidium fluitans, Spirogyra sp. Studies on the mechanism of deacylation of aminoacyl-tRNAs by aminoacyl-tRNA synthetases in the absence of adenosine monophosphate and pyrophosphate.

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Activation of PKG by 8-bromo-cGMP reduced, like CNP, cocaine-induced gene transcription in dopaminergic structures. A balloon catheter is inserted into the bladder to avoid the possibility of cystostomy. In vitro and in vivo antimicrobial efficacy of natural plant-derived compounds against Vibrio cholerae of O1 El Tor Inaba serotype. To determine if the clinically practiced method of radiographic femoral varus angle (R-FVA) measurement is repeatable, reproducible, and accurate.

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Host range studies on xenotropic type C viruses in somatic cell hybrids. Field potentials were recorded on self-paced hand and mouth movements with implanted electrodes on the surface and at 2.0-3.0 mm depth in respective cortical areas in seven monkeys. The story of how hormones influence inflammation and neuron and glial function is being slowly unraveled. These cyclic lid movements were not elicited with any eye movement or by increased accommodation. The toxicities associated with long-term steroid therapy, combined with their ineffectiveness as maintenance medications, have led to increased use of immunomodulators, such as azathioprine and 6-MP, for the treatment of steroid-dependent and steroid-resistant IBD.

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Endovascular treatment of wide-neck bifurcation aneurysms is challenging and often requires adjunctive techniques and devices. Anticancer activity and quantitative-structure activity relationship (QSAR) studies of a series of antioxidant/anti-inflammatory aryl-acetic and hydroxamic acids.

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Fetal biliary lithiasis: ultrasonographic diagnosis and clinical interpretation. Blood pressure and HR responses to exercise did not differ between groups. Based on the finding that SEH was caused by a mild mechanical trigger and neurologic deficits remained in this patient, this report highlights its diagnostic difficulty as well as the importance of rapid treatment. Thus, the switching functionality of the tetracycline-binding aptamer appears to include both a conformational rearrangement toward the regulation-competent structure and its thermodynamic stabilization. Although donor-matched skin grafts in animals tolerant to kidneys induced antidonor cytotoxic T lymphocyte responses, second renal transplants revealed no evidence of sensitization.

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The rate of polypeptide chain elongation in a cell-free system from Krebs II ascites cells. Our laboratory has demonstrated that treatment of MCF-7 breast cancer cells with melatonin (Mlt) followed 24h later with physiological concentrations of all-trans retinoic acid (atRA) results in apoptosis. STAT (signal transducer and activator of transcription) proteins have been shown to be essential transcription factors which mediate biological effects of cytokines.

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The effect of iophendylate on the concentration of formed elements, hemoglobin and nucleic acids in circulating blood The microRT hardware specifications, the accuracy of the treatment planning and positioning systems, and some typical procedures for radiobiological experiments that can be performed with the microRT device are presented.

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CYP231A2 does not exhibit structural features normally associated with thermophilic proteins such as an increase in salt bridge networks or extensive aromatic clustering. Since metabolic changes occurred under nitrogen- depleted state, the protein and carbohydrate pathways were shifted to lipid biosynthesis.

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In addition, Pro-Quest Dissertation and Thesis database and Pro-Quest Science Journals. Only the near vision subscale had adequate measurement properties (person separation, 2.30).

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Treatment of the cardiomyocyte cell line HL-1 with IL-18 induced hypertrophy as characterized by increases in protein synthesis, phosphorylated p70 S6 kinase, and ribosomal S6 protein levels as well as cell surface area. Incubation of cells with proteasome inhibitors MG-115 and MG-132 prevented the decrease in cyclin D1, D2, and D3, and cyclin-dependent kinase 4 protein. Dissecting the bacterial stress response against novel challenges: high pressure. The antibiotic salinomycin (Salin) was recently identified as an antitumor drug for the treatment of several types of solid tumors. All had progressive renal function deterioration for which no other cause was identified.

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To develop such an educational program, a baseline assessment of knowledge and self-care practices of patients, needs to be made. Respondents in the experimental group more often indicated that the feedback they received was interesting and easy to understand. At 12 months, the CMAPs indicated complete recovery, while the SEPs showed incomplete but substantial recovery. We herein report a case with suspected multiple metastases but unknown primary, who underwent endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal lymph nodes with negative results by rapid onsite cytologic evaluation, followed by the transesophageal approach with the ultrasound bronchoscope for the vertebral body lesion at the same setting that provided a definitive diagnosis of metastatic hepatocellular carcinoma.

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Retrospectively collected information on lifestyle during pregnancy, birth, and early childhood behavior is sometimes biased, which limits its value in estimating the contribution of early-life adversity to health in later life. Included among the pathophysiological changes that are speculated to occur as a secondary response to the initial ischaemia are free radical production, excitotoxicity (for example, glutamate) disruption of ionic homeostasis (for example, sodium and calcium influx), enzymatic changes, stimulation of the inflammatory process, endothelin release, activation of platelets and leukocytes, delayed coagulation and endothelial dysfunction. A detailed chromosomal banding analysis with the G-staining, C-staining and Ag-I-staining techniques revealed no significant anomalies.

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Increased activity of matrix metalloproteinases (MMPs) in the aortic wall, leading to degradation of extracellular matrix components, is considered to play a crucial role in aneurysm formation. They thought it might reduce the number of office visits patients made and help track long-term trends. The mean rCBF ratio of each region was then compared between the ataxic and control subjects. Fluorescence of chromatin DNA induced by antitumoral naphthalimides. A food web model of our experimental system-a marine rocky shore community-could reproduce these results only when biologically likely and plausible nontrophic interactions, based on competition for space and predator-avoidance behaviour, were included.

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Informatics for peptide retention properties in proteomic LC-MS. Namely, for the objectively defined weather types favourable conditions for asthma ER visits occur when an anticyclonic ridge weather situation happens with near extreme temperature and humidity parameters. Secondly, the safety of composite resins is considered and potential toxic and hypersensitive effects of these materials are discussed.

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The pitted exterior surface of the mammary tumor virus appears to be a unique surface structure. Cargo surface hydrophobicity is sufficient to overcome the nuclear pore complex selectivity barrier. Metabolic imaging of human brain tumors: H-1 chemical shift imaging and PET Our results suggest that the schedule of gefitinib followed by rapamycin, acting at different levels of the EGFR cellular pathway, could induce antitumor and antiangiogenic effects of clinical interest in the pancreas cancer model. Poliovirus-infected cells contain a previously unrecognized particle which appears to be an intermediate in virion synthesis and therefore has been named proviron.

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The pKH9 rep gene is not present in this fragment, suggesting that pKH9 can replicate in fusobacteria independently of the Rep protein. This paper represents an effort to (a) describe a theoretical model of motivation in human technology interaction, (b) provide design principles and guidelines based on this theory, and (c) describe a sequence of steps for the. In this paper we describe an approach whereby over 2000 individual polymers were synthesized, in situ, on a microscope slide using inkjet printing. Tumour necrosis factor-alpha activates a calcium sensitization pathway in guinea-pig bronchial smooth muscle.

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Monitoring respiratory signals during nonnutritive sucking and early feeding may help to identify newborns with increased risk of aspiration and assist with clinical decision making. The technics of numeric comparison of systems demonstrated a high specificity of chromatin alterations in relation to the taxonomic position of viruses. CT-guided percutaneous drainage of the lesion yielded six cc of pus, the culture of which grew E.

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This was ascribed to reduced anxiety, though this was not assessed. Early experience with a modified preloaded system for fenestrated endovascular aortic repair. The effect of bisphosphonates to prevent calcification could be associated with the physical property to attach tightly to hydroxyapatite crystals in bone matrix. Paradoxical embolism across a patent foramen ovale (PFO) is a rare clinical entity and the thrombus is rarely caught passing through a PFO.

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We examined expression of Z39Ig in 1432 human cDNA libraries, and found it primarily in synovium of patients with rheumatoid arthritis, in placenta, and in lung. We found that overexpression of the translation inhibitor Thor (4E-BP) can suppress all of the pathologic phenotypes, including degeneration of dopaminergic neurons in Drosophila. Similarly, lysine replacements occurred almost exclusively in the NA-induced revertants of only the ochre mutant cyc1-72, but not at all in the others.

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The influence of age in analysis of mortality variation between population groups. The economic attractiveness of these 2 strategies in North America is unknown. The occurrence of different conspecific female colour morphs, with one of the morphs resembling the male, is supposed to have consequences for mate choice. Non-polio virus interference with oral polio vaccine immunization: possible influence of physical climate and socio-economic status.

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Spreading depression (SD), a wave of neuron activity related to migraine and the ischaemic penumbra, features a moving shell of extracellular negative potential shift (V(o)) whose generators are poorly understood. A wide working space through the port is then made by separating the anatomical plane extraperitoneally. Postoperative ascites frequently occurred in patients with decreased liver functional reserve. As an aside, NER seems also not involved in Ig gene switch recombination.

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actinomycetemcomitans could be repeatedly isolated from an individual, the initial colonizing strain was replaced by another strain. Immunocytochemical markers in stage I lung cancer: relevance to prognosis. Right anterior aortic valve replacement minithoracotomy surgery with single-lung ventilation did not result in increased rate of respiratory system complications. This Gram-negative bacterium has a great genetic variation with a number of virulence factors.

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The intestinal microbial communities and their temporal dynamics are gaining increasing interest due to the significant implications for human health. Each received from days 1-10 (period 1): 1875 mg nelfinavir plus 200 mg ritonavir q.d.

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In addition, the kinetics of binding of fluorescein-EGF to different cells from the same coverslip often differ significantly from each other, indicating cell-to-cell variations in the binding properties of the EGF receptor. PAT-AIx relates to HTN, may be a valid measure of wave reflection, and provides distinct information from arterial stiffness. Back exchange of 18O-labeled amino acids by erythrocytes: the possible role of amino acid transport. Anxiolytic-like effects of the neurokinin 1 receptor antagonist GR-205171 in the elevated plus maze and contextual fear-potentiated startle model of anxiety in gerbils. All sound categories induced more smooth-pursuit eye movement than silence, with the greatest effect occurring with stimuli of increasing pitch.

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Phosphorylation of vesicular stomatitis virus in vivo and in vitro. The substitutions that resulted in no detectable autoinducer synthase activity mapped to two small regions of LuxI. These data suggest that there is continuous turnover of MAs during pregnancy. High potency was observed in the case of polyamine derivatives bearing two 3-aminopropyl chains on the mycosamine. Recent developments have led to prolonged survival with the use of sequential lines of chemotherapy agents.

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Botulinum neurotoxin serotype B (BoNT/B)-specific Fab was expressed in a cell-free protein synthesis system derived from an E. Gastric electrical stimulation (GES), using the implantable TANTALUS System, is being explored as a treatment for obesity. Considering the important roles of biothiols in lysosomes of live organisms, and unique photophysical/photochemical properties of ruthenium(II) complexes, a novel ruthenium(II) complex, Ru-2, has been developed as a molecular probe for phosphorescence and time-gated luminescence assay of biothiols in human sera, live cells, and in vivo. A change in production method introduces the possibility of a change in polymorphic form which may alter the photoreactivity of the substance.

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In mice, this process is believed to initiate shortly after birth with the emergence of nascent spermatogonia in the testes. Both sensitive and resistant strains appeared to be similar in virulence. Thirty three patients who underwent heart-lung transplantation were followed for a mean period of 16.3 months.

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Although it is rare, a refilled thin-walled cavity in lung may be malignant, which should be kept in mind by clinician. On the importance of sensitivity to the dose-effect relationship in chemotherapy. A multidisciplinary approach, reduction of immunosuppressive medications, combination of antibiotics, close skin surveillance and excision of suitable lesions are recommended in this specific subgroup.