FREE
SHIPPING!

on all orders above $300.00

FREE Pills!

VIAGRA PILLS

for free with every order

OUR DRUG PRICES are

70%

Less than in your
local pharmacy

Search by letter:

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Enter coupon: (if you have one)

Nicord (Amlodipine)
+ BONUS
 
Amlodipine

This paper reviews the short-term effects of the calcium channel blocker Nicord on plasma levels of cyclosporin A and its interaction with blood pressure and kidney function. Transdermal Nicord Besylate in Lipoderm for the treatment of Feline Hypertension: A Report of Two Cases.

Other names for this medication:
Amlodipine, Norvasc, Abis, Abloom, Actapin, Amlodin, Amlotens, Amlovas, Amlovasc, Amlozek, Amparo, Amtas, Amvasc, Amze, Anexa, Arteriosan, Arterium, Asomex, Astudal, Avistar, Calchek, Cardisan, Cardivas, Cordil, Coroval, Dafiro, Dafor, Divask, Dopin, Duactin, Esam, Exforge, Gensia, Hipres, Imped, Ipin, Istin, Kaprin, Lama, Locard, Lodipine, Lofral, Lopin, Monovas, Myodura, Nicord, Nipidol, Noloten, Orkal, Perivasc, Perten, Roxflan, Rustin, Stamlo, Tenox, Tensivask, Tervalon, Vamlo, Vasocard, Vazkor, Vazotal, Vilpin, Zorem,

Similar Products:
Flotac, Zoldicam, Digitek, Combutol, Lucon, Gynodel, Aspra, Fertil, Meitat, Trevilor, Almacin, Clamovid, Piramil, Oprazole, Teril, Prysma, Arteriosan, Ilgem, Noklot, Diclorapid, Gabatal, Iprox, Azelone, Aldalix, Imiject, Frusenex, Clomifene, Inmed, Suanatem, Omez, Tegretol, Zepral, Alep, Adiva, Zalat, Rispone, Metsec, Ection, Risperdal, Emidoxyn,

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

nicord and fda

Clinical course and macular retinal circulation of macular retinal epithelium atrophy Next an attempt is made to establish correlations with other techniques and results, with a view to defining any unique attributes of the technology in particular fields.

nicord and fda

The demonstrated stabilization system should prove useful for a wide range of ultrafast pulse processing and analysis applications based on the use of two-arm interferometers. It is a new aspect of preoperative risk evaluation and may indicate a potential for prevention. Basic behavior of the finite helical axis in a simple tooth movement simulation. Oral phenylalanine loading profiles in symptomatic and asymptomatic gene carriers with dopa-responsive dystonia due to dominantly inherited GTP cyclohydrolase deficiency.

nicord and fda

Stone formation after augmentation cystoplasty: the role of intestinal mucus. Little is known about the prevalence of sleep-disordered breathing (SDB) across ischemic stroke subtypes.

nicord and fda

Vascular cytochrome p450 enzymes: physiology and pathophysiology. Peak exercise capacity improves early after orthotopic cardiac transplantation. Genetic susceptibility in solvent induced neurobehavioral effects. Strains were also tested for the ability to transfer resistance either directly or by mobilization to standard strains of Escherichia coli K12. Alignment of the genomic region harbouring PiAvr4 with syntenic regions in P.

nicord and fda

The use of an intraaortic balloon pump (IABP) may play a role in such patients by improving the function of the injured heart. Healing potential of meniscal tears without repair in knees with anterior cruciate ligament reconstruction. Compared to first-generation devices, the design of newer generation drug-eluting stents may facilitate more rapid anatomical and functional healing of stented vessel based on thinner stent platforms, biodegradable/biocompatible polymers and rapid drug elution. A case of general anaesthesia for removal of carcinoid metastases is presented.

nicord and fda

The study, even if limited to the evaluation of hospitalizations, points out how HPV-related pathologies continue to be a relevant public health issue in Italy with a high impact on population. Simultaneous inference of biological networks of multiple species from genome-wide data and evolutionary information: a semi-supervised approach. It is locally infiltrative and exhibiting a high risk of local recurrence. Ten hypertensive patients with modern to severe impairment of renal function were treated with sotalol for 5 to 10 weeks (average 6.4 weeks).

nicord and fda

The authors investigated whether currently available assessment tools for prediction of cardiovascular risk can be used for individual risk prediction as a basis of informed decision making. Between June 2006 and January 2016, 6 renal cryoablation procedures were performed in 5 patients with horseshoe kidneys. Presented in this report is a 34-year-old man with an interesting case of folliculocentric tinea versicolor manifesting as perifollicular hypopigmented macules on the lower back. The red-cell enzymes, glutathione reductase (FAD-dependent) and pyridoxine (pyridoxamine) phosphate oxidase (FMN-dependent), were studied in control subjects.

nicord and fda

Psychogenic oligodipsia with hypernatremia in a psychotic patient. In addition, positional information of the stimulus is conveyed to supra-spinal circuits, and then regulates the curvature strength for appropriate escape pathway from the threat.

nicord and fda

Blood pressure, heart rate, temperature, BMI, oxygen saturation, and electrolytes are few of the physiologic factors that will soon be available to patients and their physicians almost continuously. Dose escalation for prostate cancer using the three-dimensional conformal dynamic arc technique: analysis of 542 consecutive patients. In complex with alphaHb, AHSP Pro(30) adopts a cis-peptidyl conformation and makes contact with the N terminus of helix G in alphaHb.

nicord and fda

However, cells deep into the scaffold were only observed in the PCL and CS scaffolds. Its long-term administration increases the incidence of nosocomial infections, which contributes to the high mortality rate of these patients.

nicord and fda

We report that fibroblasts from a type I CDG patient, born of consanguineous parents, are deficient in their capacity to add the eighth mannose residue onto the lipid-linked oligosaccharide precursor. This tool is an effective, theory driven, intervention that helps to protect against stress-induced high-calorie snack consumption. An overview of the report of the national commission on sleep disorders research. At the end of each hour, the work of breathing (assessed by measuring the diaphragmatic pressure time product), thoracoabdominal asynchrony and respiratory muscle strength (maximal inspiratory pressure, maximal expiratory pressure (Pemax) and maximal transdiaphragmatic pressure (Pdimax)) were assessed. Despite steady accumulations of positive findings over the last ten years, the precise role of sleep in memory and brain plasticity is unproven at all.

nicord and fda

To evaluate the association between high-risk human papillomavirus (HPV) DNA detection and histological diagnosis in women referred for atypical glandular cells (AGC) or adenocarcinoma in situ (AIS) at Pap smear. Endoscopic and laparoscopic techniques have been reported as alternatives to standard surgical techniques. During the past decade, Akt (also known as protein kinase B, PKB) has been extensively studied.

norvasc amlodipine besylate 10 mg picture

  • olmetec 40 mg olmesartan medoxomil and amlodipine
  • self nanoemulsifying drug delivery system of telmisartan amlodipine
  • simvastatin 40 mg and amlodipine 5
  • amlodipine benazepril generic images
  • nifedipine vs amlodipine for blood pressure
  • tamsulosin hcl side effects with amlodipine
  • amlodipine besylate side effects tingling sensation
  • amlodipine-benaz 5/20 mg
  • amlodipine besylate 10 mg tab dosing
  • nifedipine vs amlodipine edema treatment
  • maculopapular rash amlodipine benazepril
  • calcium antagonist amlodipine-benaz
  • s amlodipine besylate manufacturers reps
  • irbesartan aprovel vs amlodipine besylate
  • blood pressure amlodipine side effects
  • amlodipine besylate drugs company
  • what does amlodipine besylate 5 mg look like
  • calcium antagonist amlodipine benazepril
  • publix amlodipine cost
  • amlodipine besylate drug study scribd books
  • amlodipine-benaz 10/20mg side effects
  • telmisartan amlodipine combination brands hatch
  • kosar bp medication amlodipine
  • amlodipine dosage amounts of synthroid
  • amlodipine generic cvs sudafed
  • what is amlodipine besylate 10 mg
  • amlodipine-atorvastatin reviews on hydroxycut
  • amlodipine 10 mg 128
  • onset and duration of action of amlodipine 5
  • amlodipine cost walmart
  • aliskiren and the calcium channel blocker amlodipine 5
  • amlodipine dose maximum acetaminophen
  • amlodipine drug indication
  • amlodipine 10mg dosage
  • sivem amlodipine 5mg cost
  • generic amlodipine besylate
  • perindopril tert-butylamine vs perindopril arginine and amlodipine
  • perindopril amlodipine tablets 5mg
  • amlodipine 5 mg twice a day medical term
  • amlodipine commercial names
  • amlodipine besylate 2.5 side effects
  • side effects amlodipine besylate 10 mg
  • amlodipine besylate 10 mg ciplak
  • amlodipine 10 mg max dose of flexeril
  • amlodipine besylate tablet 2.5 mg
  • mode action amlodipine
  • almus pharmaceuticals amlodipine 10
  • amlodipine dosing frequency abbreviations
  • google amlodipine besylate side effects
  • amlodipine 10 mg oral tab
  • ketoprofen drug profile of amlodipine
  • amlodipine and atenolol brands
  • amlodipine benazepril lotrel coupons
  • amlodipine 10 mg c-max 2016
  • dose amlodipine besylate
  • amlodipine dosage twice a day bid
  • price for amlodipine 10 mg
  • medicine amlodipine
  • amlodipine besylate drug substance abuse
  • amlodipine besylate 2.5mg dosage
  • drug induced gingival hyperplasia amlodipine besylate
  • mechanism of action of amlodipine in hypertension treatment
  • amlodipine 10 mg adalah ialah
  • amlodipine-atorvastatin classification of matter
  • amlodipine vs beta blocker
  • amlodipine mode of action ppt slides
  • amlodipine 5 mg nhs uk
  • amlodipine use during pregnancy
  • amlodipine tablets ip 2 5mg valium
  • phthaloyl amlodipine manufacturers in hyderabad india
  • amlodipine 5mg atenolol 50 mg
  • nicord and fda
  • almus pharmaceuticals amlodipine dosage
  • amlodipine besylate 10mg tab picture crow
  • image of amlodipine besylate 10mg
  • amlodipine 10 mg adalah bennett
  • amlodipine dosage for dogs
  • amlodipine besylate side effects fatigue
  • green tea blood pressure pill amlodipine
  • amlodipine dose in renal impairment anticoagulant
  • amlodipine 10 mg reviews
  • amlodipine 5 mg dexametasona
  • amlodipine besylate 5mg tamyl medicine
  • cipla amlodipine besylate 10 mg looks like
  • amlodipine dosing pediatric patients
  • amlodipine tablets for cats ukraine
  • amlodipine-atorvastatin reviews on wen
  • amlodipine drug facts
  • mhra simvastatin 40 mg amlodipine 5
  • indapamide other drugs in same class as amlodipine
  • amlodipine information for consumers
  • norvasc amlodipine besylate 10 mg picture
  • pms-amlodipine 10 mg side effects
  • amlodipine benazepril 5 20 side effects
  • felodipine amlodipine dose conversion
  • lek amlodipine side effects
  • amlodipine besylate side effects webmd medical reference
  • amlodipine besylate side effects tingling fingers
  • amlodipine 5 mg looks like
  • amlodipine 5 mg dosage elderly patient

nicord and fda

Furthermore, peptide orientation and location within lipid bilayers was determined using tryptophan-fluorescence-quenching experiments and attenuated total reflectance infrared spectroscopy. Dentin bond optimization using the dimethyl sulfoxide-wet bonding strategy: A 2-year in vitro study. Improved purification of transducin subunits from bovine retinal rod outer segments. Waking at night to smoke as a marker for tobacco dependence: patient characteristics and relationship to treatment outcome.

amlodipine use during pregnancy

The results presented here show that lead(II) cleavages in vivo yield detailed structural information for these RNAs, which was in good agreement with the models proposed based on in vitro work. Raman and surface-enhanced Raman scattering (SERS) of 5-fluorouracil (5-FU) have been recorded under several experimental conditions. Government may decide to plan ahead when a significant exodus of cancer patients travel to another country for treatment, thus exposing the failure of the country to provide this medical service for its citizens. First, we employed an assay based on the measurement of DNA repair in cisplatin-damaged plasmid DNA incubated in the presence of cell-free extracts prepared from either rat liver or human hepatoma HepG2 cells treated by oltipraz. In group B, three of the five animals survived, all anastomoses were patent.

image of amlodipine besylate 10mg

CGH has been applied to clinical PGD and has resulted in the birth of healthy babies from embryos whose full karyotype was determined in the preimplantation phase. MP provides quantitative measurements of central macular function in CSCR that may supplement OCT findings as well as the better understanding of visual functions during the acute stage of the disease. On the other hand, there are several mutualistic associations without vertical transmission, such as those between plants and mycorrhizal fungi, legumes and rhizobia, and some corals and dinoflagellates. Anti-allergic mattress encasing may provide clinical benefit in asthmatic patients.

indapamide other drugs in same class as amlodipine

The results, taken together, are strongly indicative of the presence of two major IL-8-like lineages of CXC-chemokines in teleost. Body mass index and hypertension were determined by measuring height, weight, and blood pressure. This dosage form is gaining popularity because of its convenience. The pain was not associated with autonomic or ocular disorders, nausea, vomitting or focal neurological signs. The results concerning mental disorders at the time of the suicide attempt confirm the clear predominance of affective disorder as well as the elevated frequency of comorbidity.

onset and duration of action of amlodipine 5

After introduction of melatonin, the activity of leucocytes in peripheral blood and proliferation activity of splenocytes increase, which can play a role in the mechanisms for the genoprotective effect of the studied medication. Structural requirements for recognition of Escherichia coli initiator and non-initiator transfer ribonucleic acids by bacterial T factor.

amlodipine besylate 5mg tamyl medicine

Extrapleural pneumonectomy for diffuse malignant pleural mesothelioma: techniques and complications. Batrachotoxin, an extremely active cardio- and neurotoxin from the Colombian arrow poison frog Phyllobates aurotaenia. The focus is on the characteristics, and success and failure factors of these programmes.A multiple case study was conducted in eight regional dementia care provider networks in The Netherlands. Psychotherapies for adolescent substance abusers: 15-month follow-up of a pilot study.

cipla amlodipine besylate 10 mg looks like

Women in the MNT program had a lower risk of preeclampsia, fewer maternal hospitalization, and neonatal deaths in both types of diabetes. In addition to the targeting of drugs, also the selective delivery of genes to HSC in fibrotic livers is of interest for therapeutic purposes and a start is made in this respect. Voltammetry of the three molecules on Au(111) showed reductive desorption peaks caused by monolayer adsorption via thiolate-Au bonding.

pms-amlodipine 10 mg side effects

Compensatory changes in REM sleep time of cats during ad libitum sleep and following brief REM sleep deprivation. In cases of suspected venous occlusion, functional diagnostic information is also achieved. However, the phylogenetic relationship between these subspecies is unclear. Therapists in Improving Access to Psychological Therapies (IAPT) services are often expected to treat complex presentations of post-traumatic stress disorder (PTSD), such as individuals with multiple, prolonged or early life trauma histories and significant co-morbidity, for which they have received minimal training.

amlodipine benazepril lotrel coupons

Characterization of Staphylococcus intermedius from pigeons, dogs, foxes, mink, and horses by pulsed-field gel electrophoresis. This review introduces multifunctional optical nanosensors based on surface-enhanced Raman scattering (SERS) and demonstrates their application in live cells. We describe the case of Patient A, a 32-year-old male with symptoms of sinusitis. Energy transfer, being a key process in many of these devices, has been extensively studied in recent years. Compared with beta-catenin the N termini of Plakoglobin and Armadillo have different transactivation capacities that may explain their distinct signaling properties.

amlodipine benazepril lotrel coupons

To this effect in the present study, we have characterised the growth of fibroblasts on nano-structured sheets constituted by BaTiO3, a material extensively used in biomedical applications. It can exist in many patients who are relatively well or who have symptoms similar to irritable bowel syndrome. The nursing profession faces major changes in health and health care and nurses need to be visible in the public debate about future models of health and health care. The increased level of BDNF and NT3 mRNAs were first observed at 6 h and the labeling was enhanced at 24 h and 72 h.

mechanism of action of amlodipine in hypertension treatment

As some virulence mechanisms and certain host responses have been conserved throughout evolution, even simple organisms can be used as model hosts to help our understanding of infectious diseases. This series of interventions targeting unnecessary testing demonstrated a sustained reduction in the number of routine tests ordered, without adverse effects on clinical care. Relationships between mood state, time estimation, and selected movement speed. Results also indicated a relatively poor fit between the empirically derived groupings and clinical diagnoses. In submucosal plaque, the most abundant family or genera found were Rothia, Streptococcaceae and Porphyromonas on implants.

amlodipine besylate drug substance abuse

To determine whether mammary gland or colostral characteristics at calving could be used to predict colostral immunoglobulin G1 (IgG1) concentration or intramammary infection (IMI) and whether leakage of colostrum affects IgG1 concentration. We did a retrospective review of the charts of patients who had undergone laparoscopic segmental colectomy. To assess the association among immune activation, immune senescence, inflammation biomarkers and renal function measured by estimated glomerular filtration rate (eGFR) at inclusion and its evolution over a 3-year follow-up in HIV-infected patients with undetectable viral load. Whatever the strategy used, NER activity was not altered in liver cells. Not only is CTI effectively used in early drug development, but also in later clinical study phases (phases 3b/4) as a therapy monitoring or follow-up instrument.

norvasc amlodipine besylate 10 mg picture

The maximal increase in N-acetyltransferase was the same in denervated, reserpine-treated, isoproterenol-treated, and untreated pineal cells. The AKXD recombinant inbred mice are predisposed to a variety of leukemias and lymphomas as a result of viral integration. The mechanisms underlying age-related skeletal muscle wasting and weakness are manifold and still remain to be fully elucidated. We found the centre site to be 3.0-7.0 dB better than the anterior site above 2,000 Hz.

publix amlodipine cost

Background This study aimed to describe sexual health behaviour, alcohol and other drug use, and health service use among young Noongar people in the south-west of Western Australia. The nitric oxide (NO) donors, sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP) and spermine NONOate (SPER/NO), activated both cyclo-oxygenase and peroxidase activities of PHS. Expression of the ADAM33 gene and protein in Mrc-5 cells was assessed using qPCR and Western blotting, respectively. Prophylactic pancreas stenting followed by needle-knife fistulotomy in patients with sphincter of Oddi dysfunction and difficult cannulation: new method to prevent post-ERCP pancreatitis. Detector for an optical-fiber acoustic sensor using dynamic holographic interferometry.

amlodipine drug facts

Every cell in a multicellular organism has the potential to die by apoptosis, but tumour cells often have faulty apoptotic pathways. Novel esophageal speech therapy method in total laryngectomized patients: biofeedback by intraesophageal impedance. MicroRNAs (miRNAs) are important posttranscriptional regulators of gene expression in eukaryotes. We observed that the expressions of ADAM12 and activin A are modulated during osteoclast formation, whereas the FLRG expression seemed to remain quite constant. Dissociations in infant memory: rethinking the development of implicit and explicit memory.

amlodipine tablets ip 2 5mg valium

Scaling and root planing, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population. In the presence of thiols, the NIR fluorescence would enhance dramatically due to desorption of FR 730 from the surfaces of Au NPs, which allowed the analysis of thiol-containing amino acids in a very simple approach.

amlodipine cost walmart

A recommended integrated mechanism to enhance OSH management of blue-collar foreign workers in Taiwan. Formerly, the function of the Drosophila Ketel gene, which encodes importin-beta and is essential for the survival to adulthood, seemed to be required only in the mitotically active cells. The active site of PhX20 comprises one residue each of tryptophan, carboxyl and histidine. Exothermic isosteric heats for TCE adsorption up to -27 kJ/mol were observed and were greatest in pores of 7 and 8 A. In this growth study we have identified that the study children have three distinct growth patterns.

green tea blood pressure pill amlodipine

These animal models, ranging from invertebrates to mammals, in most cases mimic the pathological features of the human diseases. Age-dependent differences in the binding of (131-I) LH by rat testis homogenates.

amlodipine benazepril 5 20 side effects

Suppression of some artifacts of modal noise in fiber-optic systems. We had administered aerosolized rIFN-gamma in the tracheas of 30 sensitized guinea pigs which had been divided into six groups, then teated animal inhaled rIFN-gamma of 5 x 10(4), 20 x 10(4), and 40 x 10(4) concentration, BDP and normal saline respectively at 24 h, 12 h, 2 h before being challenged. Analyses of the trajectories revealed that the dynamic fluctuations of both the Hin peptide and the hixL DNA were lowered by the complex formation.

Testimonials
Best
 Show Hide 
publix amlodipine cost 2011-07-11

PE status, vessel level, and lobar location were determined by means of majority rule, and interobserver agreement (kappa) was calculated for PE status, as assessed with each modality. The long-lasting increase in excitability of spinothalamic tract cells amolex duo forte comprimidos depends on the activation of several second messenger cascades (PKC, PKA, and NO/PKG signal transduction pathways). Testing aspherics using two-wavelength holography: use of digital electronic techniques.

amlodipine besylate 2.5 side effects 2016-08-16

Age, gender, weight, body surface area, renal function, anticoagulation, coagulation variables, blood flow, arterial pressure, arterial cannulation sites, duration of support, extracranial bleeding, native cardiac function and presence of intracranial microemboli were analyzed to determine the vagimid 250 ml risk factors for intracranial hemorrhage. The procedure involves trading imagined levels of independence (resources) across different functional items (features) at different stages of recovery. Molecular engineering of two-photon fluorescent probes for bioimaging applications.

amlodipine 10 mg adalah ialah 2012-08-13

The mean regression line with double standard deviation allocated patients with rapid, normal or slow sputum conversion. To find whether elderly people with a dementia and a mobility problem show a unicam didattica online polito greater improvement in mobility skills if given physiotherapy treatment than if given non-physical activities intervention during a hospital respite admission.

publix amlodipine cost 2017-05-03

This was particularly the case when the mood and anxiety group was under stress. Larval abundance was significantly and positively associated with temperature and relative humidity at terazosin hytrin side effects site 1.

phthaloyl amlodipine manufacturers in hyderabad india 2019-04-20

For a more precise examination of swallowing function in myasthenia gravis additional technical tools are necessary. Echocardiogram and cardiac catheterization disclosed a tumor of the left atrium and the coronary arteriography was normal. Progesterone nuclear receptor levels did not greatly change (in relation to DNA content) during both phases of full deciduomal development but peak levels were observed on day 5 after decidualization. The threshold for a response to noxious heat was lowered, fluzole 150 mg nidirect and the responses to supra-threshold noxious heat stimuli were enhanced. This study analysed the impact of several factors on the start and duration of time off work among 802 patients with occupational hand injuries, in order to identify prognostic indicators.

amlodipine vs beta blocker 2015-11-03

Status of salt iodisation and iodine deficiency in selected districts of different states of India. Experience with adnexa torsion in children, a rare but potentially bactox 125 mg gaba severe pathology, is still disappointing despite constant radiological progress.

amlodipine drug facts 2019-07-12

SinemetR failed to prevent the adaptive reduction in the RMR to energy restriction suggesting that levodopa maintains the buccastem tablets vertigo medication RMR by a peripheral effect or effects. Our results suggest, however, that it is not a natural pituitary peptide but an artefact formed by enzymic degradation of beta-lipotrophin during extraction.

what does amlodipine besylate 5 mg look like 2018-08-03

Application of MLST has helped to define the population biology which may underpin the epidemiology of pathogenic E. Further investigation will be required to assess clinical response and durability, identify appropriate candidates, and define the viglast s tablets optimal angiographic technique and PVA particle size.

amlodipine tablets ip 2 5mg valium 2011-07-21

This scarcity was attributed to indiscriminate logging, overexploitation, poor harvesting methods and current agricultural trends. If this were so the data would be consistent with autosomal dominant inheritance. Selection of a prostate-specific promoter, such as the probasin (PB) and prostate specific antigen (PSA) neuralgin rx obat apazol promoters, is critical for generating sufficient levels of transgene expression to elicit a phenotypic response. A novel peroxide-induced calcium transient regulates interleukin-6 expression in cardiac-derived fibroblasts.

ketoprofen drug profile of amlodipine 2013-02-20

Alterations in either blood perfusion or oxygen delivery to the medullary region will have significant effects on both regional metabolism and total kidney function. This was a cross-sectional descriptive study using quantitative and qualitative approaches. As immigrants difference between metoprolol and lopressor dose make up an increasing percentage of the population in many developed nations, a better understanding and eliminating these barriers is a major priority.