Ezetimibe and Locol combination is used together with a proper diet to treat high cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (eg, heart attack, stroke) caused by clogged blood vessels. It is also used to treat a condition called homozygous familial hypercholesterolemia (HoFH).

Ezetimibe is a cholesterol absorption inhibitor and Locol is an HMG-CoA reductase inhibitor, or statin. These medicines will reduce the absorption of cholesterol from foods and the production of cholesterol in your body.

This medicine was available only with your doctor's prescription.

The Locol/ezetimibe combination (Liptruzet(R)) was withdrawn from the United States market on June 2, 2015.

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Purification, characterization and cDNA cloning of a phospholipase A2 inhibitor from the serum of the non-venomous snake Elaphe quadrivirgata. Thus, the present results indicate that the prolonged blockade of nitric oxide synthesis that causes arterial hypertension is associated with an activation of the sympathoadrenal system. The results demonstrate that E7-mediated destabilization of pRB does not require p53 activity and is independent of the ability of E7 to induce apoptosis.

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Intrinsic thyroid hyperactivity in avian strains susceptible to autoimmune thyroiditis. A method for isolation of Q1 was developed by combination of adsorption chromatography on silica and normal phase HPLC with an amino phase. Combined orthotopic heart and liver transplantation: the need for exception status listing. In cervical cancer, SLN biopsy and ultrastaging has high sensitivity in lymph node staging in patients with bilaterally detected SLN.

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Rabbit control and fractured ribs, after healing for three, six, and twelve hours and daily for seven days, were evaluated by light and electron microscopy. The presence of the mucin domain lowered agrin binding to several N-acetyllactosaminyl-containing saccharides and C2 myotubes and lowered agrin activity in AChR clustering.

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Electrophysiological evaluation showed a severe axonal and demyelinating sensorimotor polyneuropathy. We determined the effect of Ang II on proliferation of cultured human CVSMC.

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Stability of most important autobiographical memories and life narratives across eight years in a life span sample. The finding of hsp60 on the cell surface of mammalian cells may signify chaperone involvement in surface functions. In all examined cases, the spatial and temporal parameters measured were significantly improved. In recent years, there has been growing research interest in using nicotine replacement medications to aid smoking reduction prior to a quit attempt.

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The prognostic significance of risk factors for ischemic and hypertensive heart disease in the aged differs in many respects from that in younger persons. Studies using animal models of anxiety, as well as mouse mutants, in which the gene coding for the CRH type 1 receptor (CRHR1) was genetically deleted supported the notion that enhanced CRH/CRHR1 signaling underlies depression and anxiety disorders.

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Expression of total smooth muscle myosin and alternatively spliced smooth muscle myosin isoforms were determined by reverse transcriptase-polymerase chain reaction (RT-PCR), quantitative competitive RT-PCR, sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot analysis. The objective of this retrospective study is to evaluate the incidence of mandibular fractures in the eastern part of Libya and to present our experience in treating this type of facial fracture.

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A stimuli-responsive membrane exhibiting independent pH- and temperature-responsive behavior was fabricated from a blend of commercial polysulfone with a functional amphiphilic binary graft copolymer, namely, polysulfone-graft-(poly(isopropylacrylamide-co-acrylic acid)-random-poly(methyl acrylate)), denoted PSf-g-(P(NIPAAm-co-AA)-r-PMMA). This study shows re-elevation of TNF-alpha, EB22/5.3 and GFAP mRNA levels at 2-3 months, but only TNF-alpha mRNA was overexpressed at 6 months.

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To date, first steps are already taken to integrate the RAVEL project results into sector initiatives toward industrywide acceptance and standardization. In this retrospective case-control investigation of a 16-year experience, 100 pregnant women who underwent planned cesarean hysterectomy were compared with 37 patients who underwent cesarean delivery followed by a hysterectomy performed within 6 months.

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The responses of single fibers to tones are seen as changes in the instantaneous discharge rate which can be measured in various ways. We advocate careful history taking prior to surgery to avoid unnecessary exposure to acrylates in patients already sensitized. Trafficking defects resulting from three independent SUR1 mutations involved in the disease persistent hyperinsulinemic hypoglycemia of infancy have been described. Obese and postmenopausal women have a high prevalence of NAFLD and severe metabolic disorders.

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We recently demonstrated that odorants appeared to compete for receptor sites to act as an agonist or an antagonist. Brain ouabainlike activity has been shown to cause sympathetic excitation in two animal models of heart failure and may play a key (although presently undefined) role in neurohumoral excitation in humans with heart failure.

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Since blood flow regulation mechanisms in the splanchnic organs can be metabolic, its metabolic capacity has been studied using the mitochondrial enzyme cytochrome C oxidase as histochemical marker. Platelet membranes and 3H-IMI binding were carried out according to a standardized protocol. To investigate the production of IL-16 during differentiation of monocytes into DCs in healthy individuals and patients with AD. Implementation of hysterectomy pathway has been associated with reduction of surgical complications in benign hysterectomy settings. Induction of wild-type and the two mutant synthases in strain BL21/DE3 from genes in pET15b yielded a strong overexpression of all three proteins in approximately equal amounts showing that the mutations did not affect production of the protein in vivo and thus that the lack of activity was not due to a failure to produce a gene product.

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were used to diagnose infection, while Leishmania species identification was performed by DNA sequencing of the amplified products obtained in the HSP70 (234) targeting. In order to support trial centres an authoring system and a central data dictionary will be developed. The association is particularly strong for white males, and weaker or non-existent for other race by sex groups.

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Koch, 1845) and Platythomisus sudeepi Biswas, 1977 from India (Araneae, Thomisidae). Dependence of the concentration of maternal serum markers on the haptoglobin gene The discovery of new molecular targets and the subsequent development of novel anticancer agents are opening new possibilities for drug combination therapy as anticancer treatment.

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Together, these results shed new light on mechanisms that drive the transcription cycle and point to a role for Fcp1 in the recycling of RNAPII after dissociation from active genes. Both effects were larger the further posterior an electrode was located in the hippocampus. By adding 6 equiv of acetyl bromide, we can get single (5-oxo-2,5-dihydrofuran-3-yl)benzyl bromide other than the corresponding benzyl acetate. The conditional double knockout mice also displayed novelty induced hyperactivity in novel open field test. A total of 412 dermatofibromas (from 292 patients) with complete documentation were collected.

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Busulfan-mediated endothelial damage is believed to be a common mechanism in a variety of vascular disorders that occur during haematopoietic stem cell transplantation. Moreover, this type of urea sensor can be repeatedly regenerated by using a simple washing treatment with 0.01 mol l(-1) NaOH (containing 0.5 mol l(-1) NaCl) and 0.01 mol l(-1) HCl. Distortion product otoacoustic emissions demonstrated bilateral inner ear (outer hair cell) damage. Questionnaire surveys of 103 female family planning clinic (FPC) patients and 40 Diploma of the Faculty of Family Planning (DFFP) instructing doctors. Effects of d-amphetamine and pentobarbital under concurrent fixed-ratio schedules.

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To report the use of endovascular grafting to repair degenerative aneurysmal changes in an extra-anatomic bypass graft. Although it is much more challenging to design metalloproteins than non-metalloproteins, much progress has been made in this area, particularly in functional design, owing to recent advances in areas such as computational and structural biology.

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It is demonstrated in this article that the cascading effect and the derivative loss can be significantly reduced by effective risk management. Cumulative genetic damage in hematopoietic stem cells in a patient with a 40-year exposure to alpha particles emitted by thorium dioxide. In this report, we describe a microdesign and fabrication approach capable of iteratively refining three-dimensional bacterial interfaces in periods as short as 10 minutes, and demonstrate its use to drive fluid transport by harnessing flagellar motion. Here, we analysed the effect of Escherichia coli K-12 colonization on the tumour microenvironment by immunohistochemistry and fluorescence microscopy in the murine 4T1 breast carcinoma model.

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The effects of pre-treatment of mice with saline or 20mg/kg of morphine plus the nitric oxide synthase inhibitor 7-nitroindazole (7NI) (12.5 or 25mg/kg) on the place conditioning induced by a low dose of morphine (2mg/kg) were assessed. Initial epigastric sensation, initial fear, delayed oroalimentary and elementary upper limb automatisms, delayed loss of contact, long seizure duration, and absent or rare secondary generalizations were associated with M seizures. One of the isolated clones encoded a new protein named VIK that belongs to the Kruppel-like zinc-finger gene family.

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Studies of insect cytokines will broaden our understanding of the basic mechanisms underlying the interaction between host innate immunity and pathogenic agents. RNA extracts from myometrial tissues were subjected to reverse transcription. These data provide a histopathologic rationale for the minimal morbidity and efficacious nature of this technique demonstrated in clinical studies. The inhibition of the type I IFN anti-cancer response pathway by AFB1 suggest a novel mechanism by which AFB1 may induce hepatocellular carcinoma in humans. Parallel cultures induced with adeno-, influenza A or rhinoviruses did not show a similar correlation.

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They have single amino acid substitutions (K244E and R273H) within the WD motif of the p48 subunit of DDB, and the mutated proteins lack the damaged-DNA binding activity. In the light of recent findings, DA-D3 dopamine receptors with an unclear physiological function are present in the cerebellar cortex.

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Comparative effectiveness of botulinum toxin versus non-surgical treatments for treating lateral epicondylitis: a systematic review and meta-analysis. This article provides a brief review of the neural bases supporting this effect with a focus on functional neuroimaging studies of perception and episodic memory. A novel assay utilizing immuno-labeling, filtration, and electrochemistry for the rapid detection of bacteria has been optimized for the detection of Escherichia coli O157:H7.

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The nematode genomes align surprisingly well despite high neutral substitution rates. The heme oxygenase enzyme system generates the majority, if not, all of the endogenous CO. Nonlinear principal components analysis was applied before cluster analysis.

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The depth dose rate results have been compared with theoretical calculations using a Monte Carlo simulation of the x-ray production process. A 17-amino acid peptide of the middle region (Arg469-Arg485), denoted Peptide 4, which possesses two N-terminal arginine residues and a C-terminal B-B-X-X-B motif (where B and X are basic and non-basic residues, respectively) bound selectively to Gi1 and Gi2, activated phospholipase C-beta3 via the betagamma subunits, inhibited adenylyl cyclase, and induced smooth muscle contraction, in similar fashion to the selective NPR-C ligand, cANP4-23. These findings suggest that induction of CD95-L by cytotoxic drugs is modulated by the cellular redox state and mitochondria derived ROS. We sought to measure utilities for stage-dependent outcome states of CRC.

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Pedicle screws are often used to manage axial instability of the spine. Eighteen 10-week-old female New Zealand white rabbits were randomly assigned to three groups with six animals in each group. Hypoxia is a common characteristic of solid tumors and is associated with poor prognosis.

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When fused to a heterologous DNA binding domain, that of the yeast transactivator GAL4, the conserved C terminus of T3R alpha functions as a strong ligand-independent activator in both mammalian and yeast cells. To describe endocrine dysfunction associated with traumatic brain injury in a dog.

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Living in counties with no municipal water fluoridation, increased exposure to environmental smoke, minority race, living in rural communities, and increasing age were the largest significant contributors (respectively). EEG showed slow, suppressive waves and high-amplitude slowing wave pattern, which is generally observed clinically in hyperammonemia in man and animal.

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Dropout in clinical trials of antipsychotic medications corresponds with efficacy outcomes, the dynamics of symptom change and baseline symptom severity. Only the TP53 gene was mutated at significant frequency across all samples.

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Emergent general surgical diseases encompass a broad spectrum of anatomy and pathophysiology, creating challenges for outcomes assessment, research, and surgical training. This review has shown there have been many pilot and demonstration projects in rural and urban Australia that confirm the effectiveness of retinal photography-based screening for DR.

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MAPK pathway mediates the protective effects of onychin on oxidative stress-induced apoptosis in ECV304 endothelial cells. Impact of a commercial peat moss operation on water quality and biota in a small tributary of the Richibucto River, Kent County, New Brunswick, Canada. Our findings yield insight into the normal physiological responses of the hippocampus during memory processes and provide compelling in vivo electrophysiological evidence that the hippocampus is involved in both acquisition and retrieval of consolidated memories. In this context, I try to explain the background of the recommendation of vitamin D2 for CKD patients.

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Bipolar Disorder (BD) is characterized by impairments in psychosocial functioning with occupational disability being one of the most significant. To determine the independent risk factors for late-onset ventilator-associated pneumonia (VAP) in trauma patients receiving selective digestive decontamination (SDD). The polymorphism was observed using polymerase chain reaction-based restriction analysis. Additional data, such as exposures and covariates can be identified from narrative text and used to conduct case-control studies. The nociception genes painless and Piezo are required for the cellular immune response of Drosophila larvae to wasp parasitization.