Ezetimibe and Lipibec combination is used together with a proper diet to treat high cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (eg, heart attack, stroke) caused by clogged blood vessels. It is also used to treat a condition called homozygous familial hypercholesterolemia (HoFH).

Ezetimibe is a cholesterol absorption inhibitor and Lipibec is an HMG-CoA reductase inhibitor, or statin. These medicines will reduce the absorption of cholesterol from foods and the production of cholesterol in your body.

This medicine was available only with your doctor's prescription.

The Lipibec/ezetimibe combination (Liptruzet(R)) was withdrawn from the United States market on June 2, 2015.

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Two reviewers independently evaluated the methodology of the studies using the STARD (Standards for Reporting of Diagnostic Accuracy) criteria. In the years 1992-2000, in the Department of Paediatric Surgery and in the Department of Pathology and Intensive Care of Newborn at the National Research Institute of Mother and Child in Warsaw, 539 newborns were surgically treated (congenital anomalies of gastrointestinal tract, genito-urinary system, central nervous system, defects of abdominal wall and diaphragm).

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Importantly, we demonstrate that TLR4 and TLR9 regulate disease severity in MOG-induced EAE. Correlation between serotype and in-vitro antibiotic susceptibility of pneumococci isolated in Saudi Arabia. Non-invasive assessment of liver fibrosis in C282Y homozygous HFE hemochromatosis. Pigment anomalies of the skin in the human chimaera: their relation to systematized naevi. Nasal congestion may also affect personal well-being and quality of life.

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Food remnants are the foreign bodies most frequently aspirated by young children. The lower-end values of normal flow rate and bicarbonate concentration were 0.15 ml/min and 1.800 mmol/l, respectively. A major challenge in tuberculosis control is the diagnosis and treatment of latent tuberculosis infection. Two-color immunolabeling on disaggregated cells confirmed that CR3 and c-fms proteins are expressed on the same cells. Observational studies that examined the association between developmental defects of enamel and dental caries in the deciduous dentition were included.

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Alcoholic extracts were made of green, black and undyed hypoallergenic shoe leather, and the extracts were fractioned by paper chromatography. The fluorescence level on these organs showed a dose-dependent response.

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One can also choose the control day to have the same temperature as the event day. Uncovering the cathepsin system in heart failure patients submitted to Left Ventricular Assist Device (LVAD) implantation. We show that infection of human fibroblasts with HCMV is associated with upmodulation of Fas-R process that could be further potentiated by interferon (IFN-gamma).

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However, plasmids containing nt 948 to 2113 were efficiently packaged, suggesting that this 1.2-kb fragment contains a packaging enhancement sequence (PES). The results suggest that the amphipathic N-terminal segment of the alpha-helix is mainly responsible for the increase in permeability of the membrane to kill the bacteria. We used alpha-fetoprotein (AFP) knockout mice (Afp(-/-)) to study the mechanisms by which estrogens affect the sexual differentiation of the GnRH1 system. In conclusion, patients with gallstones may present a functional disorder in the secretion of gastrointestinal hormones involved in gallbladder motility.

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Here we collect together and review these past experiences and the studies currently underway. Effects of isoproterenol on the toxicity in rats of compounds eliminated by the kidneys. Our findings reinforce the concept that ET-1 may be implicated in the pathogenesis of bronchoconstriction. Carrier status, history of personal cancer, pre-test levels of optimism or multidimensional health locus of control did not significantly predict distress at T3.

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The ventilation /perfusion scanning has been the preferred examination for several decades, but with the development of new tests the diagnostic possibilities have increased. Our results aim to provide a fundamental and rich resource for exploring aphid functional genes in A. Identification of the human chromosomal region containing the iridogoniodysgenesis anomaly locus by genomic-mismatch scanning.

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The recent development of nonradioactive automated assays for serum parathyroid hormone (PTH) and 25-hydroxyvitamin D (25OHD) has made measurement of these two hormones possible in many laboratories. Inclusion criteria were that the studies contain original content assessing the treatment of lower eyelid retraction in humans using a spacer graft and provide quantitative outcomes data. The 10-day PPI/AM re-treatment regimen is safe and effective, suggesting its usefulness as second-line treatment in Japan in patients who have failed initial treatment with the PPI/AC regimen. Should an inquiry about sexual health, as a reflection of vascular health, be part of routine physicals for young men?

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To examine childhood polyclonal and allergen-induced cytokine responses in parallel to evaluate cytokine imbalances in childhood atopic disease. Its structure was identified via NMR and mass spectroscopic studies.

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Levels of aminoacylation and ribosomal attachment during hemoglobin synthesis. The 590-amino-acid precursor of PA protease is composed of a putative 19-amino-acid signal sequence, a 165-amino-acid N-terminal propeptide, a 33 kDa mature protease domain and an 11 kDa C-terminal propeptide. Response of chick-embryo kidney cells in vitro to two avian tumor viruses. However, the regulation of HIF-1 alpha in neonates with hypoxia-ischemia (HI) is not clear.

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After vitrectomy, the physician reported a successful cryotherapy reaction at the treated tear. During the study session, subjects memorized a series of stimuli (faces). They communicated with interdisciplinary colleagues about ways to improve outcomes and identified and implemented changes in practice that resulted in improvements. Activator-mediated stimulation of the assembly of the preinitiation complex has been studied in vitro but has been relatively refractory to in vivo analysis.

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The ability of dental practices to remain productive and profitable over time depends on their capacity to serve patients comprehensively. Also, the need for graft nephrectomy and chemoprophylaxis remains unclear. After the glass-breaking process, a spontaneous self-detachment of a fiber-like structure occurs that can be exploited as an alternative way for fabricating glass cantilevers.

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The DNA-DNA hybridization method was used to estimate the value of intergenomic divergence of sequences of middle and thermostable fractions among representatives of three classes of echinodermata (Echinoidea, Asterodea and Holothurioidea), and also representative of another type, ascidian Halocynthia aurantium. Systemic sclerosis is a complex disease manifesting itself by fibrosis of skin and other internal organs. The social and clinical characteristics of patients with recurrences and their treatment outcomes are presented in the paper.

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We report a case of a 28-year-old man with angiosarcoma of the spleen and liver metastases. The data do not support the hypothesis that combined therapy improves the well-being and general health of patients. Pretreatment of cells with either LY294002 or MbetaCD abolished the inhibitory activity of both APC and thrombin against sPLA(2)-IIA expression, suggesting that the protein C occupancy of EPCR confers a PI3-kinase dependent protective activity for thrombin such that its cleavage of the lipid-raft localized PAR-1 inhibits the TNF-alpha-mediated expression of sPLA(2)-IIA in HUVECs. Flunitrazepam, Althesin and phenobarbitone caused a significant increase in the activity of the enzyme which was not observed with propanidid, etomidate and minaxolone. It is necessary to perform cannulation of the LIMA, in order to diagnose and treat these patients.

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However, it is generally inadequately controlled in CKD patients. The regular and light-dark Suok tests of anxiety and sensorimotor integration: utility for behavioral characterization in laboratory rodents.

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This study describes the features of distal focal femoral deficiency, potential orthopaedic concerns, and proposes a classification scheme for this pathology. The longer the patients remained in the trial the more that they improved, with trial completers showing the most improvement at each time point. The grandchildren were born between 1981 and 1993 on the Northern Plains.

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Parathyroid cysts: description of two cases and review of the literature. Besides particle yields and biological activity, the most important concern is improving vector purity. However, embryos treated with the same dose of gamma-IR after the midblastula transition developed normally and exhibited no signs of apoptosis, no change in cyclin A1 level, and no increase in cyclin A1-Cdk2 activity. Increased tumor thermal dose efficacy studies in larger patient populations for improved breast conservation should be investigated. In particular, considerable attention is devoted to the CYP2D subfamily, which is a group of highly polymorphic enzymes.

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Furthermore, we show that Mind bomb (Mib), a ubiquitin ligase that promotes Notch ligand trafficking and activity, is a crucial molecular substrate for PAR-1. The additional morphological descriptions and comparisons presented here further support the view that Arboroharamiya, as a derived haramiyidan, shows similarity to multituberculates in tooth and mandible morphologies.

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The aim of this study was to define the function of T-lymphocytes during development of postirradiation pneumonitis and pulmonary fibrosis. It is demonstrated in the present study that the class C beta-lactamase from Enterobacter cloacae P99 has reached the diffusion limit in its ability to hydrolyze its preferred cephalosporin substrates. The histopathological features of lesions resected from children with Proteus syndrome predominantly include hamartomatous mixed connective tissue lesions, benign neoplasms such as lipomata, and lymphatic-rich vascular malformations. Their actin cytoskeleton exhibits a characteristic arrangement that is dominated by dense, stationary actin foci at the side walls, in conjunction with less dense dynamic regions at the leading edge. Prevalence of hepatitis G virus RNA and antibodies to HGV envelope protein (anti-E2) in patients with liver injury in Japan

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Gastrin-cholecystokinin(B) receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the epidermal growth factor receptor. Here, we perform high quality Born-Oppenheimer molecular dynamics simulations of the reaction mechanisms associated with hydrogen-assisted CO2 reduction on Ni(110). Knowledge of resource use and associated costs of treatment, care and rehabilitation at hospitals and in the health care and social service sectors is limited. Treatment with recombinant mouse MFG-E8 attenuated inflammation and lung injury in murine neonatal sepsis.

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Elongator fails to affect the phosphatase activity of Fcp1 in vitro, but genetic evidence points to a functional overlap between Elongator and Fcp1 in vivo. Since 1985, the Regional Pharmacovigilance Centres have received about 341 reports of undesirable effects due to herbal medicines: among them 30 cases of hepatitis were reported associated with germander which has been now withdrawn from the French market. Plasma high-density lipoprotein cholesterol and socioeconomic status. This cross-sectional study investigated 114 people living with HIV who were taking antiretroviral medication using the HIV/AIDS-related Stigma Scale (Chinese version), the Social Support Rating Scale, the Center for Epidemiological Studies Depression Scale, and the Medical Outcomes Study-HIV health survey. No significant association exists between the technique of sterilization used and a change in duration or amount of bleeding.

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Given the promising results, this laboratory prototype should be reengineered to a clinical applicable instrument. The blocks from primary carcinomas also contained normal prostatic tissue (40 cases), benign prostatic hyperplasia (16 cases), and high-grade prostatic intraepithelial neoplasia (32 cases).

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Constitutively active ESCRT-II suppresses the MVB-sorting phenotype of ESCRT-0 and ESCRT-I mutants. Therefore, to broaden the spectrum of detection and to reach more maltreated children, who are less likely to be visible to CPS, it is necessary to train and support school professionals because of the frequency of their contacts with children on an almost daily basis. Less attention has been given to the mechanical performance of MSWI BA in actual civil engineering structures. To obtain information about the relationship between cardiovascular and diabetic risk factors of mothers and their children and to determine whether these relationships differ by physical activity or ethnicity.

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The complete nucleotide sequence and multipartite organization of the tobacco mitochondrial genome: comparative analysis of mitochondrial genomes in higher plants. Elderly patients may be deficient in their ability to clear drugs from the body due to declining lung, kidney/bladder, gastrointestinal and circulatory efficiency.

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Using an algorithm based on local over-representation and comparative genomics, we identified putatively functional transcription factor-binding sites (TFBS) in TATA-dependent proximal-promoters. They are nonencapsulated, poorly circumscribed, often lobulated, and largely extraconal in location. Endocardial electrogram analysis after intramyocardial injection of mesenchymal stem cells in the chronic ischemic myocardium. The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation. Determination of alpha1-antichymotrypsin-PSA complex in serum does not improve the differentiation between benign prostatic hyperplasia and prostate cancer compared with total PSA and percent free PSA.

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These results demonstrate that myopes are less sensitive to the presence of blur, and may at least partially explain why previous reports have demonstrated a larger lag of accommodation in this refractive group. Partial projection and stepladder-artifacts are occurring predominantly close to the diaphragm, where the displacement is most prominent.

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The study comprised 50 soft-tissue tumours, diagnosed by ultrasonography or histopathology as belonging to one of 5 soft-tissue tumour groups. To investigate the effects of aerobic and strength exercise on motor fatigue of knee flexor and extensor muscles in subjects with multiple sclerosis (MS). Structural polymorphism of the luciferase gene in the firefly, Luciola lateralis.

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A functional green fluorescent protein-erythropoietin receptor despite physical separation of JAK2 binding site and tyrosine residues. The Abs discriminated between the different PAH-NAC conjugates and NAC-BSA. The acceleration of the head in the direction of the ballistic path was the strongest in absolute value. rosettR is implemented as a package for the statistical computing software R and provides easy to use functions to design an experiment, analyze the images, and generate reports on quality control as well as a final comparison across genotypes and applied treatments. A large interindividual variation in EPT-associated MD change has been observed, but few studies have investigated genetic predictors of the EPT-associated MD change.

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In studies on animals (rats, rabbits) an experimental technique for estimation of microhemocirculation parameters of tissue under treatment has been developed. The effect of bacteria and serum on superoxide production by granulocytes. Population genetics for three STR loci in the population from southern China.

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Mechanistic and therapeutic perspectives for cardiac arrhythmias: beyond ion channels. The current and potential roles for this type of interferon in the treatment of hepatitis C virus infection are considered.