Topical Klindan comes as a foam, a gel, a solution (liquid), a lotion, and a pledget (swab) to apply to the skin. The foam and one brand of the gel (Clindagel) are usually applied once a day. The solution, lotion, pledgets, and most brands of gel are applied twice a day. Apply topical Klindan at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use topical Klindan exactly as directed. Do not apply more or less of it or apply it more often than prescribed by your doctor.

Topical Klindan is only for use on the skin. Do not swallow the medication, and do not get the medication in your eyes, nose, mouth, or vagina. If you do get the medication in your eyes, nose, or mouth, or on broken skin, rinse it out with plenty of cool water.

Your medication will probably come with directions for use. Read these directions and follow them carefully. Ask your doctor or pharmacist if you have any questions about how to apply topical Klindan.

Shake the lotion well before each use to mix the medication evenly.

The pledgets are for one-time use only. Do not remove a pledget from its foil pouch until you are ready to use it. Dispose of each pledget after you have used it one time.

The foam may catch fire. Stay away from open flames and do not smoke while you are applying the foam and for a short time afterward.

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De novo formation of focal adhesions in HUVECs was significantly diminished in the presence of NO donors. Rare Frequency of Mutations in Pituitary Transcription Factor Genes in Combined Pituitary Hormone or Isolated Growth Hormone Deficiencies in Korea. This progress now makes it possible to incorporate quaternary stereocentres selectively in many organic molecules that are useful in medicine, agriculture and potentially other areas such as flavouring, fragrances and materials. Samples were collected over a 4-month period in several habitats, including marsh, irrigation channel, lagoon, and mangrove swamp during the wet season and the wet-dry transition. The results of the present study support the hypothesis that alterations in 5-HT system might be related to alcoholism.

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Discovery and phylogenetic analysis of a riverine species flock of African electric fishes (Mormyridae: Teleostei). Specialized breast centers have accumulated sufficient experience to recognize that HER2 positive tumors tend to be of higher grade and to be estrogen receptor negative, whereas well-differentiated breast cancers rarely are HER2 positive.

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We have previously demonstrated that exogenous progesterone, but not oestrogen, upregulated lymphocyte beta 2-adrenoceptors (beta 2-AR) when given during the follicular phase in healthy females. (CEA 15.1 ng/ml, CA19-9 93 U/ml to CEA 4.4 ng/ml, CA19-9 29 U/ml) Then, an expandable metallic stent (EMS) could be inserted to the stenotic common biliary duct after radiation therapy. VLBW subjects did not differ significantly from their controls in self-perceived health, use of tobacco, education, occupation and way of living, or scoring on SF-36 and Sense of Coherence. The transformation is induced with cholic acid analogues or saponins which cause reversible disruption of the bacterial membrane.

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Nevertheless, there is a paucity of autopsy and imaging data that can be used to describe the optimal size and location of lesions or the location of implantable stimulators. Effects of a restrictive fluid regimen in pediatric patients undergoing major abdominal surgery. Lipoprotein lipase (LPL) is a crucial enzyme in lipid metabolism and transport, and its enzymatic deficiency causes metabolic disorders, such as hypertriglyceridemia. Extensive use of new information will open a range of ethical issues that we must face timely. The rats were anesthetized and subjected to an I/R insult consisting of 30-min left anterior descending coronary artery (LAD) occlusion followed by reperfusion.

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In addition, multiple personal, social, behavioral, economic, and environmental factors may interact to positively or negatively influence recovery during the different stages of rehabilitation. The objective of this study was to calculate and compare the effective dose and to estimate risk from the use of intraoral position-indicating devices of differing geometries. Significant correlation between environmental and exhaled air isoflurane concentrations allowed the establishment of a biological exposure index and biological exposure limits corresponding to proposed atmospheric threshold values. There was a statistically significant improvement in the intern group between the overall pre-test score and the overall post-test score.

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VR duration and dispersion responses to a very rapid HR increase during normal conduction differed substantially. After fusion, the phospholipid component of the vesicles mixes relatively rapidly with cell membrane lipids as judged by the immunofluorescence pattern of cells fused with lipid vesicles containing trinitrophenylated lipids. We examined the immunosuppressive effects of aflatoxin B1 (AFB1), a toxic compound produced by the Aspergillus flavus, on murine peritoneal macrophages after in vitro pre-exposure. This feature makes FRET a powerful tool to study complicated biological assemblies. The concepts, techniques, and materials for root end filling have been evolving.

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Earlier results on the existence of genes affecting variability are revisited in the context of effects of phase-shifts on lifespan. Hepatitis B surface antigen, subtype ad, was purified and studied by sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions. GSLs levels (glucoallysin, glucobrassicanapin, gluconasturtiin, glucobrassicin, 4-methoxyglucobrassicin, neoglucobrassicin and 4-hydroxyglucobrassicin) and their gene expression levels (BrMYB28, BrMYB29, BrMYB34, BrMYB51, BrMYB122, CYP79 and CYP83) significantly increased in hairy roots compared with that in non-transformed roots. CAR (2.5 and 5 mg/kg) treatment significantly improved behavioral abnormalities and biochemical and cellular alterations as compared to control. Symplastic communication spatially directs local auxin biosynthesis to maintain root stem cell niche in Arabidopsis.

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We recorded systematically positive blood-cultures and days with intravenous antibiotics. Adhesion molecules in atopic dermatitis: upregulation of alpha6 integrin expression in spontaneous lesional skin as well as in atopen, antigen and irritative induced patch test reactions.

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Genomic signatures of near-extinction and rebirth of the crested ibis and other endangered bird species. Values for the 3 protocols did not differ significantly in either the cochlea or vestibule. X-ray microanalysis of leakage from polyphosphate granules in Scenedesmus.

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CBP and its homologue p300 are targets for several viral-transforming proteins, implying that these co-activators have a more extensive role in cellular function. Further developments should not only be based on research, but also consider the diverse experiences of other countries, and they should incorporate appropriate structures for monitoring and evaluation. Several researchers have previously reported that another important hallmark of biofilm formation is development of increased tolerance to various antimicrobial measures and treatments.

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We report here the derivation of three new substrains of mice each carrying a single M-MuLV genome on different chromosomal integration sites. In order to perform these measurements the system takes a picture of the skin. We surveyed, within a year of their cholesterol measurement, 250 randomly selected men and women who had had their cholesterol checked by physician order between January 1993 and 1994. The relationship was explored between biomarkers, ICP, CPP, CT-scan classifications and the clinical outcome. Both face groups were evaluated by 117 university graduates (65 men and 52 women) and 103 non-graduates (49 men and 54 women) between 23 and 41 years old.

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Cloning and disruption of the ornithine decarboxylase gene of Ustilago maydis: evidence for a role of polyamines in its dimorphic transition. It is easily adaptable to other reporters, however, whether naturally fluorescent or requiring immunochemical staining. Cytoplasmic extracts exhibited temperature-sensitive leucyl-tRNA synthetase activity. As predicted, the results showed that moderately to severely dysphoric individuals have attentional impairments.

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The relationship between oral malodor, gingivitis, and periodontitis. Peptide discovery platforms now allow robust access to potent, highly functionalised peptides against virtually any protein of interest, with typical binding constants in the nanomolar range. We recorded also anthropometric measures, pulmonary function, CF severity scores, and plasma nutritional and inflammatory parameters (proteins, vitamins, erythrocyte fatty acids, and micronutrients).

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to provide conditions for assessment of effectivity of tuberculosis control methods, to collect and evaluate data on basic economic aspects of tuberculosis control, 4. Readiness for smoking cessation was assessed using the smoking stages of change (SSC) short form questionnaire.

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Expanding wave solutions of the Einstein equations that induce an anomalous acceleration into the Standard Model of Cosmology. Rapid diagnostics are urgently required given the large numbers of suspected enteric fever patients with a negative culture. Exercise training improves both the QOL, especially the mental component, and the exercise tolerance in patients with left ventricular dysfunction. Staphylococcus aureus is the leading cause of hospital-acquired infections in many countries, and multiple factors contribute to the ability of these bacteria to disseminate and spread in hospitals.

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Factors influencing the delineation of the role include the changing needs and goals of patients, families, interdisciplinary team members, healthcare institutions, and the community as well as the knowledge, skills and experience of the CNS. The results of this trial do not support inclusion of newborn vitamin A supplementation as a child survival strategy in Ghana. To systematically review the current scientific literature and discuss legislation and regulations that have been implemented to prevent the disease. The echocardiographic diagnosis of a rare complication of an aneurysm of the sinus of Valsalva Endogenous opioids regulate moment-to-moment neuronal communication and excitability.

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The release of 40S hnRNP particles by brief digestion of HeLa nuclei with micrococcal nuclease. Heparanase (HPSE1) is elevated in various types of cancers including cervical cancer, and correlated with poor prognosis. Moreover, these leaves offer unique opportunities to investigate important phenomena in evolutionary biology, such as repeated evolution or convergent evolution of similar morphological traits. Methamphetamine (METH) is a drug of abuse which can cause apoptosis and degeneration of monoaminergic terminals in the mammalian brain. In conclusion, these data show that endogenous melatonin is an essential part for an accurate response of human lymphocytes through the modulation of IL-2/IL-2 receptor system.

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Less Skilled Young Soccer Players on Anthropometric, Maturation, Physical Fitness and Time of Practice. Hematopoietic progenitor/stem cells immortalized by Lhx2 generate functional hematopoietic cells in vivo. Although these mutant strains do not form fruiting bodies, many of the cells encapsulate within the mounds. A study of subclasses of proteolytic enzymes in salmon roe and the published data suggest that the activity of proteinases may be related to the presence of aspartyl proteinases (cathepsin D).

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Neuropsychology across the Lifespan: Proceedings of the Third Meeting of the Federation of European Societies of Neuropsychology. Mitochondria filling the cytoplasm in a type of juxtamacula cell revealed uniformly dense COX reactivity. Especially, at least 18 residues from the N terminus of VP1 are transiently externalized. Articles comparing the results of clinical evaluation to polysomnography (PSG) were selected. This example illustrates finally the various possibilities of combination of in vitro and in vivo experimental approaches.

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The self-assembling properties of these compounds were studied by X-ray powder diffraction, optical microscopy, and electronic microscopy. Thirty fluoroquinolones susceptible isolates as determined by presence of all wild-type gyrA bands on the Genotype MTBDRsl assay were also included. It appears that members of an underresourced community regard socioeconomic and service delivery aspects of their lives as integral to their perceived state of health. A model of a transmembrane drug-efflux pump from Gram-negative bacteria. We made use of a recently published algorithm that performs an exhaustive conformational search using a rotamer library to enumerate all possible sidechain conformations in a binding site.

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The FXR activators, all-trans farnesol and juvenile hormone III, also accelerated epidermal barrier development. Three weeks after suture removal, keratoplasty was performed (donors C57BL/6 mice). Retrospective chart review, a mailed survey, and telephone interviews. Serial contrast-enhanced MRI may detect the diminished perfusion that is related to the graft rejection or vascular complications. This preliminary analysis indicated that automated analysis of the effects of alternative splicing would provide a rich source of biologically relevant information.

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Compared to previously established genome browsing databases, YNA provides a powerful gene mining and retrieval interface, and is an investigation tool that can assist users to generate testable hypotheses for studying chromatin regulation during transcription. DAs related to the shape, number, size, and structure of teeth were investigated.

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Three new aromatase inhibitors have recently completed phase III evaluation as treatment of metastatic breast cancer in post-menopausal women whose disease has progressed despite tamoxifen therapy: anastrozole (ARIMIDEX, Zeneca), letrozole (FEMARA, Novartis) and vorozole (RIVIZOR, Janssen). Mandarin speech perception in nucleus CI 24 implantees using MAPs based on neural response telemetry. Included were education about sleep and nightmares, instruction in writing new dream narratives and practicing guided imagery, and support via further consultation and trouble-shooting. Two granulocytic regions in bone marrow with eosinophilia evaluated by flow cytometry.

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Axillary lymph nodes marked with a clip can be localized and selectively removed to accomplish targeted axillary dissection, which is technically possible after chemotherapy and is easily performed with other axillary surgery, such as SLN dissection. Since posterior communication is also associated with a high rate of healing complications, it is another indication for open reduction. The subjective postural vertical in standing: reliability and normative data for healthy subjects. Overview of chronic cholestatic conditions in adults: terminology and definitions. The bladder cancer seems an ideal model for diagnostic and therapeutic approaches using regional administration of McAb conjugates via a catheter direct into the bladder.

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Those patients who presented punitive God representations were able to begin the process of re-creating these representations toward more benign or benevolent images in the context of this group, while those participants who presented depersonified God representations seemed unable to do so. A total of 4,600 retrieval oocyte cycles were finished between July 1, 2004 and April 30, 2006.

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This, in the short term, has provided satisfactory prevention of postoperative impingement. This study highlights a number of gender- and age-specific findings with regards to sun protection. The highest transduction of human hematopoietic progenitor cells was achieved with vector supernatant generated from a coculture of the ProPak-X and ProPak-A cell lines. Balance and functional abilities are controlled by both sides of the body. Similar vascular loops may develop in hemi-central retinal vein occlusion (hemi-CRVO).

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Human trafficking is a major global public health problem and represents a substantial human rights violation. Endothelial monocyte-activating polypeptide-2 is increased in pregnancy but is not further increased in preeclampsia. Although monomer penetration into the enlarged collagen network has been widely discussed as the possible mechanism of the dentin bonding agent and dentin primer, the true detailed mechanism of the dentinal bonding agent and dentin primer should be consistently explained by the prevention of monomer diffusion into the dentin and water contamination of the adhesive interface. The effect of nutlin-3 on HIF-1alpha function was examined by reporter analyses, immunoprecipitation and immunoblotting.

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A cohort of patients with chronic discogenic low back pain who had failed to improve with comprehensive nonoperative care demonstrated a statistically significant improvement in pain, physical function, and quality of life at 2 years after IDET. Oesophagobronchial fistula caused by varicella zoster virus in a patient with AIDS: a unique case. We have shown that it can form homodimers and heterodimers with Sdc25p.

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Bacillus subtilis Pro-sigmaE fusion protein localizes to the forespore septum and fails to be processed when synthesized in the forespore. A modified reactive Delphi technique was constructed and three survey iterations were administered. A systematic search docking procedure GRAMM-X was applied to a comprehensive nonredundant database of nonobligate protein-protein complexes to determine the size of the intermolecular energy funnel. Intermittent administration of furosemide versus continuous infusion in the postoperative management of children following open heart surgery.

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The oxidation restored significant but reduced catalytic activity, consistent with the proposed roles of Asp-48 as a nucleophile and general base. Furthermore, using both mammalian two-hybrid and immunoprecipitation experiments, we show that AR and HDAC1 interact, suggestive of a direct role for down-regulation of AR activity by HDAC1. Action of insulin on contraction and electrical responses of rat skeletal muscle For 19 TDM tests, the majority of laboratories did not have alert values to report values over the therapeutic level but not toxic. Decreased PMN accumulation and glomerular damage by clodronate liposome treatment in PMN-dependent anti-GBM nephritis in mice.

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Spectral resolution of four cytochrome b components in mitochondria. Pulmonary endarterectomy is a successful treatment of chronic thromboembolic pulmonary hypertension. Direct incorporation of experimental phase information in model refinement. The range of lesions in the small intestine of children with celiac disease determined by capsule endoscopy. The stomach presented three portions: cardias, fundus and pylorus.

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A direct neural role in the regulation of immunoreactive glucagon (IRG) secretion has been investigated during stimulation of mixed autonomic nerves to the pancreas in anesthetized dogs. Leptin concentration is increased in patients with the obstructive sleep apnea syndrome (OSAS). In a patient with WPW syndrome and idiopathic dilated cardiomyopathy, intractable atrioventricular reentrant tachycardia (AVRT) was iatrogenically induced. In this study, using a derivative of proOmpA containing an artificial stop-transfer sequence (proOmpA2xH1), we analyzed the process of stop-transfer during translocation across the cytoplasmic membrane of Escherichia coli. A variety of proteins, including transcription factors, molecular chaperones and protein tyrosine phosphatases, are regulated via redox processes.

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In healthy elderly subjects, the 200 mFWT requires a more sustained effort than the 6 MWT. Hg analysis of the TCLP extracts was done with USEPA Method 7470A. Effect of procainamide on left ventricular performance in patients with primary myocardial disease. Immunohistochemistry localized PTN protein on hepatic nonparenchymal cells, mostly stellate cells and some of Kupffer cells, and the preneoplastic nodules in fibrotic liver tissues. Diagnostic guidelines for bipolar disorder: a summary of the International Society for Bipolar Disorders Diagnostic Guidelines Task Force Report.

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The product progression during polygalacturonate cleavage showed a typical depolymerization profile for each enzyme and demonstrated their endolytic character. Microglia in the tumor microenvironment: taking their TOLL on glioma biology. Axam has been identified as a novel Axin-binding protein that inhibits the Wnt signaling pathway.

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After challenge with OVA, eosinophilia was suppressed in the lungs of the CpG-treated mice. Characterization of the dopamine-responsive adenylate cyclase of bovine parathyroid cells and its relationship to parathyroid hormone secretion. The overall frequency of isolation was 10.3 per cent and 2.3 per cent for poultry originating from southern China and Hong Kong, respectively. Damage to the posterior temporal bottleneck predicted deficits on all tasks, while damage to the anterior bottleneck only significantly predicted deficits in verbal fluency. Type 2 diabetes is associated with an increased risk for cardiovascular disease.

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We sought to correlate faculty clinical evaluations with medical student performance on a written, standardized EM examination of medical knowledge. Wood CO(2) efflux and foliar respiration for Eucalyptus in Hawaii and Brazil. Impact of growth hormone therapy on adult height of children born small for gestational age. These studies show for the first time that I3C in an injectible form has anti-prostate cancer activity. Extracellular p.s.p.s recorded from single synaptic spots showed the same characteristics of facilitation as those of intracellular p.s.p.s in the same muscle fibre, suggesting that individual synaptic contacts on any single fibre are similar to each other.4.

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An automated image analysis program determined the time point of transition from regional contraction to relaxation activity, and calculated T(R), defined as the time, in milliseconds, from the electrocardiogram R-wave to this transition point. Facile synthesis of methotrexate intercalated layered double hydroxides: particle control, structure and bioassay explore. Dietary exposure of finfish to aromatic contaminants and tissue distribution. Recent experimental studies have shown that people code time in terms of a mental timeline which typically runs from left to right or from back to front. Amino acid composition analysis indicated that Aze was not incorporated into de novo synthesized class I sHSPs.