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Two of the mutations, I53C and I70C, were found to significantly prolong the half-life of the enzyme in detergent solution. Reliability of inspiratory capacity for estimating end-expiratory lung volume changes during exercise in patients with chronic obstructive pulmonary disease. Nutritional status of the elderly: dietary and biochemical findings. Only 11 cases involving Nocardia asteroides spinal osteomyelitis have been reported over the past 40 years.

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Furthermore, IFN-gamma KO mice had significantly higher plasma IL-10 concentrations but did not exhibit impaired bacterial clearance or increased mortality following Pseudomonas challenge. Placing an implant in an ossified cochlea is technically difficult. Together, these results indicate that deregulation of the cell cycle in these mutants results from two separate mechanisms, one of which is related to calcium homeostasis. Murine mammary tumor cell clones with varying degrees of virus expression.

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Production and characterization of human cell-adapted murine Rauscher virus pseudotype of murine sarcoma virus. AACR meeting review, the Homestead, Hot Springs, VA, USA, 14-18 October 1998.

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She underwent a weekly administration of paclitaxel (90 mg/body) as a second-line chemotherapy. Aromatase inhibitors can also be used for neoadjuvant therapy of breast cancer in which they have achieved better therapeutic efficacy than tamoxifen. We examined agreement between ethnicity in records of a sample of members of five Northern California Kaiser Permanente medical centers with self-reported ethnicity.

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Effects of gamma-hydroxybutyric acid (GHB) in opioid-dependent patients. Brain tumour disease is a severe disease with dramatic manifestations and it is important that this time be kept as short as possible. In our study, we pretend to evaluate prevalence and eventual relation among microalbuminuria, diastolic disfunction and left ventricular hypertrophy, in young mild to moderate hypertensive patients, non diabetic and without previous treatment. Lipid loading of RAW 264.7 cells and mouse peritoneal macrophages with either oxidized or acetylated LDL significantly inhibits the growth of C pneumoniae.

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This perspective illustrates some outstanding structural and functional synthetic models of the active site of copper proteins, with special attention given to models of galactose oxidase and hemocyanin. There is an urgent need for coordinated research into perinatal and childhood stroke and the recently formed International Paediatric Stroke Study group (IPSS) will hopefully contribute much to improving our understanding and management of these children. The -250 DHS became undetectable in cell lines representing a transition from colon adenoma to carcinoma, commensurate with a significant reduction in MUC1 expression. Epidemiological evidence regarding dental status and its relationship to diet and nutritional status has been limited.

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Culturally relevant care would include alternatives to hormone replacement therapy in education materials about the perimenopausal transition for midlife Filipinas. Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes.

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Measurement of adenylylcyclase activity in the AV nodal region of the canine heart: evidence for inhibition by adenosine and acetylcholine. A wide range of methods have been developed including antisense DNA, ribozymes, decoy RNAs, transdominant proteins and suicide vectors targeted at disrupting Rev function. Arthroscopy to address hip injuries in athletes can result in substantial improvement with durable results. This study describes the light microscopic and ultrastructural features of a leiomyosarcoma localized to the sellar and suprasellar region in a 35-year-old man.

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Our data suggest that gckA and ttuD might be structural genes for glycerate kinase and that the serine cycle and the tartrate utilization pathway share a series of reactions. Tuberculosis induced hypogonadism in affected women which seemed to be reversed on treatment. In 2012, we reported 30 compound data sets and/or programs developed in our laboratory in a data article and made them freely available to the scientific community to support chemoinformatics and computational medicinal chemistry applications.

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We insert small spacers made of methylmethacrylate, which can be placed between the bone of the acetabulum and the acetabular component, preventing voids or thin areas in the cement coat. Contrary to the reports in the literature the polymerase appears not to bind to the UP element whereas the phage-specific factor does. The release of cytotoxic granule contents by cytotoxic T lymphocytes triggers apoptotic target cell death. In conditions of stress, cardiomyocytes mount an adaptive response that attempts to normalize ventricular wall stress and maintain cardiac output. Experimental work, mainly on rabbits, was reviewed and complemented with the results of calculations on the thermal changes in the ocular media.

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Anterograde labelling experiments coupled with immunocytochemical detection further showed that 5-hydroxytryptamine1B receptors in the substantia nigra are located on axons of striatal neurons. Pilonidal sinus is an acquired condition, penetration of hair is the main cause, and the disease can be prevented if the aetiological factors are understood. Cholix toxin is an ADP-ribosyltransferase found in non-O1/non-O139 strains of Vibrio cholera. There are, however, some concerns and negative implications and awareness of these should afford a better appreciation of when and where the model can be most usefully applied. The enterotoxin domain of PO-13 NSP4 exists in amino acid residues 109 to 135, a region similar to that reported in SA11 NSP4.

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Dorsal root ganglion (DRG) stimulation has shown great promise, particularly in conditions where traditional SCS has fallen short. The assay also proved to have a detection range of the same magnitude as that used for detection of L. Studies that involve tagSNP selection for an admixed population should not be generally correlated with any specific HapMap population and can be better represented with a pooled dataset in most cases.

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We undertook this study to investigate whether three times weekly urokinase rinsing of CVC reduces the incidence or severity of CVC-related infections by CoNS in patients undergoing intensive cytotoxic treatment for hematologic malignancies. ERU avoids the problem of requiring a predefined putative relative utility, which has limited application of utility theory in receiver operating characteristic analysis. Nucleosome ordering with a 210 base-pair periodicity in a highly ordered ten-nucleosome array appeared to result from linker histone-dependent alignment with respect to each of two positioned nucleosomes, approximately 1000 base-pairs apart. Association of the IFNAR1-17470 and IL-10-592 cytokine variants with susceptibility to chronic hepatitis B viral infections in a Chinese population.

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Women gained weight modestly, on average, 0.17 kg during the 6-year study period. Raloxifene modulates interleukin-6 and tumor necrosis factor-alpha synthesis in vivo: results from a pilot clinical study. Food and Drug Administration List of Drugs NOT to be Used in Compounded Medications for Humans (The Negative List).

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Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene cause tissue-specific tumors, with a striking genotype-phenotype correlation. The overall oxygen affinities of the alpha and beta subunits in both iron and cobalt hemoglobin tetramers were increased by the removal of this arginine residue and that of the alpha subunits was markedly influenced as compared with the beta subunits.

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Based on these observations, we cannot draw a definitive conclusion that intraspousal transmission of GBV-C/HGV had occurred among these seven couples. Changes in growth, photosynthetic activities, biochemical parameters and amino acid profile of Thompson Seedless grapes (Vitis vinifera L.).

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Dose-response assessment strategies for endocrine-active compounds. We confirmed that patient and graft survival is comparable between SPK and KA recipients.

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Phosphatidylcholine expression was examined molecularly by the use of time-of-flight secondary ion mass spectrometry, along with biochemical solid-phase extraction. Judicious management of anticoagulation, prevention of renal failure and aggressive correction of thrombocytopenia may help to lower the risk of intracranial hemorrhage in adults on extracorporeal membrane oxygenator support.

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The modulating influence of cyclic nucleotides upon lymphocyte-mediated cytotoxicity. To perform a pharmacoeconomic evaluation of the efficacies of therapeutic schemes involving four hepatoprotective drugs for the treatment of drug-induced liver injury (DILI).

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The use of marine-derived bioactive compounds as potential hepatoprotective agents. Comparison groups controlled for exposure to the CS, and repeat testing.

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Providing sexually transmitted disease education and risk assessment to disengaged young men through community outreach. The present study examined the relationship between weight and depressive symptoms over time in older adults in South Korea. The G1862T mutation in HBV occurs in the bulge of the encapsidation signal within the pregenomic RNA.

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Comparative analysis of neuropeptide cleavage sites in human, mouse, rat, and cattle. We combined the UK Renal Registry paediatric and adult databases to describe patient characteristics, transplantation and survival for young adults. The latter enzyme is probably responsible for the crystalline substructure of these peroxisomes. This finding was most pronounced in subjects with diabetes in the family, but it was also indicated in those without a family history of diabetes. This implementation is applied to magnetic resonance data acquired along radial-lines and spiral trajectories through Fourier transform space.

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Epidemiological evidence suggests that a dietary deficiency of vitamin C may be a risk factor for hypertension. Drug effects on drug targets: inhibition of enzymes by neuroleptics, antimycotics, antibiotics and other drugs on human pathogenic amoebas and their anti-proliferative effects. Qualitative interviews were conducted with 30 men and 30 women with chest pain, age 45 to 64, living in two socioeconomically divergent areas of Glasgow, Scotland. We determined whether hepatitis C virus (HCV) RNA could be detected associated with peripheral blood mononuclear cells (PBMC) of seropositive blood donors who had spontaneously or therapeutically cleared their plasma viremia. With progressive renal disease, structural derangement increasingly encompasses the tubulointerstitial compartment.

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5 x 10(5) tachyzoites of FABZ defective mutant were cultured in HFF in the presence of anhydrotetracycline (ATc, 1 microg/ml) for 24 h and 48 h, respectively. We found higher left amygdala/hippocampal activation during the luteal phase and higher right amygdala/hippocampal activation during the follicular phase. In this study, we showed that ERK-2/MAPK is associated with simian immunodeficiency virus (SIV) virions and regulated the nuclear transport of Vpx and virus replication in non-proliferating target cells by phosphorylating Vpx. At the individual level of analysis, measures of personality (i.e., Agreeableness and Conscientiousness) predicted peer ratings of team member performance beyond measures of job-specific skills and general cognitive ability. pneumoniae proteins and their role as T cell activating antigens and Th1/Th2 balance in C.

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In this article, the most common psychological problems in the cosmetic and aesthetic field of work are presented. Excellent clinical results can be achieved after ACL reconstructions performed soon after injury using autograft hamstrings. The resultant urine organic acid profile showed a mild dicarboxylic aciduria but lacked the glycine conjugates characteristic of MCAD deficiency. To characterise epidemiological and clinical findings, and diagnostic procedures undertaken, in cats with lymphosarcoma at a veterinary teaching hospital.

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The percentages of T-cells bearing the VA5-1, VA17-1, VA19-1, VB2-1, VB8-3 and VB13-1 subfamilies were significantly increased following infiltration of the brains in infected mice. Variant Creutzfeldt-Jakob disease (vCJD) is a fatal and untreatable neurological disease, in which pathogenic prions (PrPSc) are involved. However, 8.48 and 16.96 microM sanguinarine caused a second mode of cell death, oncosis, distinguished by cell surface blistering, and neither caspase-3 activation nor PARP cleavage. Despite the generally favorable opinion of physicians about NHPs, physician preference for working with other physicians in conjunction with a rapidly increasing supply of primary care physicians may greatly limit future employment opportunities for NHPs. The integrated outcomes showed that the ongoing reporting and transferring system in general hospital was benefit for TB case detection.

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Preparative solvent partition chromatography of butyrylated cyclic AMP analogues. A Markov model was used to model 10-year progression of RA in patients first diagnosed with undifferentiated arthritis (UA) and to estimate the incremental costs and quality-adjusted life years (QALYs) of using aCCP additionally to American College of Rheumatology (ACR) criteria. Major barriers identified to meeting these needs included organizational difficulties, professional barriers and shortages of appropriate training and resources. Vascular leakage following cardiopulmonary bypass contributes to morbidity.

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Several plant organs contain proteinase inhibitors, which are produced during normal plant development or are induced upon pathogen attack to suppress the enzymatic activity of phytopathogenic microorganisms. Interestingly, most var genes and var-related unspliced cDNAs described so far are of A/B hybrid type. Class II IN mutants, on the other hand, display pleiotropic defects, most notably in virion morphogenesis and/or reverse transcription.

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Screening for carnitine palmitoyltransferase II deficiency by tandem mass spectrometry. Weight-modification trials in older adults: what should the outcome measure be? As this syndrome is uncommon in pediatric practice, complex differential diagnostic search and delays in the diagnosis are frequent. Warfarin for the prevention of systemic embolism in patients with non-valvular atrial fibrillation: a meta-analysis.

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Early identification of motor dysfunction in preterm infants with very low birth weight (VLBW) is important in order to provide early intervention. Together, results demonstrate that working memory load increases the application of heuristics during spatial decision making, particularly when participants attempt to maintain quick decisions while managing concurrent task demands. A new technique of attachment of flexor tendons to the distal phalanx without a button tie-over. NHRs also play important roles in the control of periodical processes, the most recently implicated being circadian rhythm. Intraexaminer and interexaminer reliability was assessed using the intraclass correlation coefficient.

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The first encounter of the virus with the host might be through binding to attachment receptors, such as the C-type lectins DC- and L-SIGN, which might play an important role of infection for a large number of enveloped viruses by capturing, concentrating and transmitting infectious virions. Cell therapy of liver diseases with human biliary tree stem cells (hBTSCs) is biased by low engraftment efficiency.

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When blocking the bladder outlet by balloon catheters, adequate bladder filling volume was achieved. The pearl steel wire: a simplified appliance for maxillomandibular fixation. 5-Bromo-2-deoxyuridine-labeling cell proliferation assay showed that G0/G1 arrest was achieved at lower concentration of vanillin (200 microg/ml) while cell cycle analysis by flow cytometer showed that G2/M arrest occurs at higher concentration of vanillin (1000 microg/ml).

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We show for the first time that this scale-invariant activity spans four orders of magnitude in awake mice. Moreover, the only functional groups borne by the phosphorylated polystyrene resins involved in factor IX-polymer interactions are phosphodiester groups. It is not known how these population-level parameters relate to single-cell properties.

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Exploring the mechanism of formation, we found that LDL- can be produced in plasma in the absence of oxygen following LDL incubation with oxidized hemoglobin species. All couples had engaged in unprotected sex for a period of over 1 year. While the bulk of these experiments were performed in C2C12 cells, identical results were obtained using mouse skeletal muscle extracts. However, these systems remain to be characterized and their main application is as experimental models to study the processes of early oocyte and follicle development.