Atovarol is used together with diet, weight loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Atovarol is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol ('bad cholesterol') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol ('good cholesterol') in the blood. Atovarol may also be used to decrease the amount of cholesterol and other fatty substances in the blood in children and teenagers 10 to 17 years of age who have familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally). Atovarol is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats with Atovarol has been shown to prevent heart disease, angina (chest pain), strokes, and heart attacks.

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Despite confirmed fluctuations in memory function measured through a neuropsychological assessment, the results showed consistent BE in all groups across test modalities, confirming the near universal nature of BE. Here we review current knowledge on the possible role for the GM in the regulation of bone metabolism and propose that the GM might be a novel therapeutic target for osteoporosis and fracture prevention.

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Aspirin and risk of multiple myeloma in adults: A systematic review and meta-analysis. There is growing evidence that neurocognitive function may be an endophenotype for mood disorders. Most of the factors involved in the pathogenesis of gastroesophageal reflux disease (GERD), previously described in European, Australian, and American studies, are present in Chinese patients with GERD, but at a lower scale.

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Pharmacokinetics of sirolimus (rapamycin) in subjects with severe hepatic impairment. Six months after the operation there was no evidence of weight reduction. Pseudomigraine with temporary neurological symptoms and lymphocytic pleocytosis.

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One of the reasons is that there is not the simple and easy tool of the fall prediction. Identification of the progenitors of Indonesian and Vietnamese avian influenza A (H5N1) viruses from southern China. The term respect is pervasive in biomedical ethical literature and in all disciplines.

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Emergency medicine training: is undergraduate training sufficient for the Swiss health-care system? Application of commercial calibrators for the analysis of immunosuppressant drugs in whole blood. CPAP exposure of premature infants with respiratory distress syndrome is protective against chronic lung disease, intraventricular hemorrhage and sepsis compared to mechanical ventilation.

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Evening primrose oil is widely used by many midwives to hasten cervical ripening in an effort to shorten labor and decrease the incidence of postdates pregnancies. The final sample in the literature review consisted of 20 articles. Detection of cardiac injury is crucial since it may facilitate early therapeutic measures.

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In a randomized controlled trial, missing data led to biased results regarding anxiety. The computer system may also provide ongoing surveillance for other types of nosocomial infections.

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Effect of remifentanil on tracheal intubation conditions and haemodynamics in children anaesthetised with sevoflurane and nitrous oxide. Convergent ecosystem responses to 23-year ambient and manipulated warming link advancing snowmelt and shrub encroachment to transient and long-term climate-soil carbon feedback. LdT joins the increasing number of antiviral agents for the management of chronic HBV infection. Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are rare but severe adverse reactions with high mortality.

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Differential display combined with a regulated transient expression system. Several hypotheses regarding cause and pathogenesis in KTS exist, but none explains all KTS characteristics completely. Crystal structure of the EF-Tu.EF-Ts complex from Thermus thermophilus.

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To determine by meta-analysis whether angiotensin-converting enzyme (ACE) inhibitors improve exercise tolerance in patients with symptomatic left ventricular systolic dysfunction (LVSD). Reticular control of the vestibular nuclei: physiology and pharmacology. pyogenes strains, M18 strains bind the complement regulators factor H, FHL-1, and C4b-binding protein through two distinct cell surface proteins. Chemical synthesis of 4-trifluoromethylumbelliferyl-alpha-D-N-acetylneuraminic acid glycoside and its use for the fluorometric detection of poorly expressed natural and recombinant sialidases.

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Investigations on both healthy and sick of viral hemorrhagic septicemia artificially reared trouts aged one and three years were carried out. Finally, Us11 protein expression induced in cells an enhanced survival to heat shock. Thus, we have identified recombinant PstS1 antigen as a potent immunotherapeutic drug for cancer therapy.

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This review provides evidence that cell culture systems can be used to demonstrate synergistic interactions between chemical carcinogens, tumour promoters and a viral agent in the transformation of mammalian cells. The ZIKV genome evolved rapidly from the Flavivirus genus and diverged from the members of this genus, even within the dengue virus cluster to which ZIKV belongs. Medical education is a vast speciality, making it difficult as a generalist to keep up-to-date in all its areas. Second, the Episode Classification System will create retrospective severity adjusted Episodes of illness or Episodes of Care.

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We modeled the read depth for all data as a mixture of Dirichlet-multinomial distributions, resulting in significant improvements over previously used models. New insights into the role of interleukin-6 in human prostate cancer. Patients with UPS were identified among the OSAS patients, who came for a CPAP therapy checkup to our sleep laboratory. The gene encoding I-mf (Mdfi) maps to human chromosome 6p21 and mouse chromosome 17.

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Subject to the limitations of the study, we concluded that the attention problems of fourth-grade Dutch children are not worsening. Novel measurement for automated interference pattern analysis of the diaphragm.

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Adolescent mothers and their children are at high-risk for depression and the associated negative educational, social, health, and economic outcomes. To elucidate the imaging characteristics of well-differentiated hepatocellular carcinomas (HCCs) on ultrasonography (US), computed tomography (CT), and magnetic resonance (MR) imaging. This indicates that from 0.2 to 0.4 M NaCl another structure is formed, consisting of just the diblock copolymer and the homopolymer, because at 0.12 M NaCl the lysozyme-PAA42-PAAm417 complex has disintegrated. Differently from platelets, B16F10-assembled prothrombinase complex was inhibited by prothrombin fragment 1 but not by fragment 2.

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We investigated whether injection of synthetic small interfering siRNAs via renal artery followed by electroporation could be effective in silencing specific genes in glomerulus. Epidermal growth factor receptor-immunohistochemical detection and clinical significance for treatment of primary breast cancer. Correction to: Trade-offs between and within scales: environmental persistence and within-host fitness of avian influenza viruses. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts. The objective of this study was to determine the diagnostic performance of a RDT approved by the US Food and Drug Administration compared with traditional thick and thin blood smears for malaria diagnosis.

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Fish and apoptosis: studies in disease and pharmaceutical design. Amniotic fluid--an important factor in fetal development (a review of the literature)

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During the growth of PROb colon carcinoma cells intraperitoneally injected in syngeneic BDIX rats, intratumoral concentration of TGF-beta1 increases while NO concentration stays very low. Validation study of the French version of the Edinburgh Postnatal Depression Scale (EPDS): new results about use and psychometric properties. Models of infantile undernutrition in rats: effects on brain lipids. Human xenograft tumors in immunodeficient mice were evaluated for histological effects and tumor response to intratumoral injection of an oncolytic HSV mutant.

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This led to various improvements regarding animal welfare in the quality control of clostridial vaccines. An interpolation method is described for range measurements of high precision altimetry with repeating intensity modulated continuous wave (IM-CW) lidar waveforms using binary phase shift keying (BPSK), where the range profile is determined by means of a cross-correlation between the digital form of the transmitted signal and the digitized return signal collected by the lidar receiver. Resection of foregut-derived duplications by minimal-access surgery. Until clinical trials demonstrate the best treatment sequence, individualized therapy is required for each patient based on patient and disease characteristics. Evaluation of a rapid one-step immunochromatographic test and two immunoenzymatic assays for the detection of anti-Treponema pallidum antibodies.

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Integrin subunits alphav, alpha6 and beta1 but not alphaL, beta2, beta3 and CD44 and CD44v6 were expressed on the cancer cells. HCV infection does not seem to be involved in the etiopathogenesis of this syndrome. A young man presented with pulmonary embolism and was found to be suffering from this condition. Although the three-dimensional structure of the DNA-binding domain of the glucocorticoid receptor has been known for several years, the crystal structure of the ligand-binding domain of the receptor has been published only recently. Ureteral frozen section analysis during radical cystectomy: Do margins matter?

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At concentrations of NAAGA required to achieve approximately 50 percent complement inhibition, PLT activation, and caspase-3 activity were increased. Measuring and tracking eye movements of a behaving archer fish by real-time stereo vision. Pharmacological approaches to stable chronic obstructive pulmonary disease. Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma.

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The diagnosis of pouchitis was made according to the modified pouchitis disease activity index. and impact of culture media on biosynthesis of antimicrobial metabolites. The temperature, pH and concentration of free phosphate were monitored during the first 80 min of reaction. Using site-directed mutagenesis, we have identified PM II residues that interact with N-terminal amino acids of peptide substrates.

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Direct imaging of AMPA receptors in various cell compartments is important to dissecting the regulation of distinct steps in receptor membrane trafficking. The stated WTP in hypothetical HIV vaccine trials was high among Chinese IDUs. This placebo-induced modulation of the readiness potential suggests that placebos reduce fatigue by acting centrally during the anticipatory phase of movement, thus emphasizing the important role of the central nervous system in the generation of fatigue.

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An antiapoptotic role for c-Myc was clearly demonstrated by specific inhibition of c-myc expression with antisense oligonucleotides, and this correlates with loss of the antiapoptotic protein Mcl-1, and, consistently, ectopic expression of c-Myc abrogates B-cell death induced upon JAK2 inhibition. We performed this phase I trial to evaluate the combination of paclitaxel with doxorubicin. The contrast enhancement pattern of the pituitary gland and surrounding arteries was assessed visually and by use of time-density curves. The approach allows detection of several targets in a one-tube assay. For speech perception, bimodal (audio-visual speech cue) or unimodal speech cues with counterpart irrelevant noise (auditory white-noise or visual gum-chewing) were delivered to 15 subjects.

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Thirty-one families with an obese 8- to 12-year-old child entered treatment, with complete dietary data provided from 20 families. The procedure requires less conscious sedation and no fluoroscopic control, but allows all conventional endoscopic interventions.

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Fetal heart rate, umbilical artery time-averaged velocity and variability in umbilical artery flow velocity were not essentially different between the two groups. In PDT, an increase in the dose of light resulted in an increase in the cytotoxicity of MB. Temporal trends in HTLV-I seropositivity rates were examined during the study period.

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The repellent was distributed among 57 intervention villages with around 25,000 inhabitants by a team of village distributors. Spontaneous and light-induced compound action potentials in the isolated eye of Aplysia: initiation and synchronization. Prenatal diagnosis can be difficult especially if they present in late gestation.

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We sought to determine whether infant and maternal levels of soluble CD14 (sCD14) are associated with the atopic outcomes of infants. Establishing trimester- and ethnic group-related reference ranges for fructosamine and HbA1c in non-diabetic pregnant women.

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The advantages a lipid vesicle protocell would have had over the other potential types of protocells are discussed. All respondents reported onset factors supporting a sociocultural etiology. Mishaps and accidents to aircraft make many travellers apprehensive and fearful of flying, a condition which most overcome by rationalisation and thought blocking, others develop a phobia for flying. In animal models, the luteinizing hormone surge increases progesterone (P4) and progesterone receptor (PGR), prostaglandins (PTGs), and epidermal growth factor (EGF)-like factors that play essential roles in ovulation.

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Findings support conceptualizing voluntary association participation among older adults as part of life course trajectories of participation, with influences originating as early as adolescence. Chinese Academy of Preventive Medicine--National Cancer Institute Benzene Study Group. However, depressive symptoms were not associated with habitual smoking motives.

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Of 60 patient informants, 38 had sought treatment for the relief of symptoms, and 22 were diagnosed by physical examination. Bench-to-bedside review: acute respiratory distress syndrome - how neutrophils migrate into the lung.

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We have shown previously that CA1 glutamatergic transmission is decreased in the CA1 subfield well before any morphological deterioration of the CA1 cells is visible under the light microscope. Studies on the antifungal effect of an ointment containing diethanolamine compared with Mycodermine ointment We evaluated the effect of consumption of two experimental probiotic-containing cheeses on the oral colonization of Candida in denture wearers. The three distributions are invariant in some sense under the transforms of the DNA group, indicating that the three distributions are inherent for the sequence. Chronic thromboembolic pulmonary hypertension is an under-recognized condition, affecting more patients than previously thought.