Ezetimibe and Cardyn combination is used together with a proper diet to treat high cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (eg, heart attack, stroke) caused by clogged blood vessels. It is also used to treat a condition called homozygous familial hypercholesterolemia (HoFH).

Ezetimibe is a cholesterol absorption inhibitor and Cardyn is an HMG-CoA reductase inhibitor, or statin. These medicines will reduce the absorption of cholesterol from foods and the production of cholesterol in your body.

This medicine was available only with your doctor's prescription.

The Cardyn/ezetimibe combination (Liptruzet(R)) was withdrawn from the United States market on June 2, 2015.

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OnEX provides a user-friendly web interface to explore information about changes in current life science ontologies. Clinical manifestations included short stature, characteristic facies, mesomelic brachymelia, brachydactyly, camptodactyly, duplication of thumbs, hypoplasia of clitoris, and deformed pronated foot. This study identified social representations of mental illness by community agents in a Family Health Program unit. Experimental study of a ceramic microsparging aeration system in a pilot-scale animal cell culture. After 492 persons were excluded who had undergone cataract surgery, data on 2788 subjects were available.

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Our findings show a higher incidence of spina bifida in Malawians than in Caucasians and Orientals, but the incidence was lower than Omani subjects. The presented statistical algorithm is shown to be an accurate and practical tool for reference interval calculations. Acute Atraumatic Splenic Hemorrhage: Babesiosis or Acute Infectious Mononucleosis. Wrist tendons may be affected by a variety of pathologic conditions, including those caused by trauma and overuse, inflammatory and metabolic disorders, or infection.

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Supplementing GC cultures with recombinant IL1A significantly lowered Fshr expression in these cells. Two hypothetical cohorts of 60-year-old men with acute deep venous thrombosis. In that individual the etiologic factor was previous esophageal surgery for stricture. This experiment aimed to evaluate if the local delivery of male sheep embryonic stem-like (ES-like) cells into osteochondral defects in the femoral condyles of adult sheep can enhance the regeneration of articular cartilage.

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For this purpose, chemically linked fragments, diabodies, scFv-scFv tandems and bispecific miniantibodies have been investigated. The transformant with an rgpA deletion showed the same LOS profile as E. As a novel stem cell source, pericytes are generally considered to be the origin of MSCs. speltoides had a homeoallelic speltoid gene, which was designated as Q(S). Femtosecond laser-assisted penetrating keratoplasty: stability evaluation of different wound configurations.

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The influence of cell hybridization between B77 virus producing RBI rat cells and L cells on B77 virus and avian Gs antigen production. The results showed that relative phase variability was higher for the fastest frequency after the exhaustive exercise. Evidence of an affinity threshold for IgE-allergen binding in the percutaneous skin test reaction. Does microdamage accumulate with age, and is the accumulation of damage with age sufficient to cause a fracture? Protein synthesis and antioxidant capacity in aging mice: effects of long-term voluntary exercise.

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To evaluate the validity and reliability of three-dimensional (3D) landmark-based palatal superimposition of digital dental models using Ortho Mechanics Sequential Analyzer (OMSA). This article reviews the NK receptors important in NK-mediated cytotoxicity in allogeneic haematopoietic stem cell transplantation. A review of 30 cases of proven pericardial effusions revealed that the diagnostic accuracy of this method is virtually the same as that of M-mode scanning and, furthermore, that by using both methods some of the pitfalls of M-mode scanning can be avoided. This review focuses on the physiological roles that these two receptors play and the implications of heme functioning as their ligand.

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In conclusion, frozen sections and antibodies raised from recombinant TGF-alpha should be used for TGF-alpha immunohistochemistry in the colon. Study of the interocclusal distortion in impressions taken with different types of closed-mouth trays and two types of impression materials. Paired sera from ten patients were investigated by plaque reduction neutralization test (PRNT) in order to confirm the HI/IF results.

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Bilateral agenesis of diaphragm, herniation of abdominal organs and oesophagus and pulmonary hypoplasia were noted. Describe total pain theory and apply it to research and practice in advanced heart failure (HF). It may be superimposed on axial myopia, probably related to polygenic factors that determine myopia in the general population.

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It is concluded, that the model is capable of studying and quantifying multisensory integration in human stance control. Acquired temperature-sensitive paralysis as a biomarker of declining neuronal function in aging Drosophila. A transposon-like element, similar to that found downstream of the region containing the promoters for mtrR and mtrC in Neisseria meningitidis, was identified 63 bp downstream of the mtrE gene.

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There are significant variations in the practice pattern of the management of stage I seminoma of testis among radiation oncologists in Canada and a selected group in the United States. This article examines the historical basis for the divergence of neurology and psychiatry over the past century and discusses prospects for a rapprochement and potential convergence of the two specialties in the next century. Hereditary spinocerebellar ataxia (SCA) is a cluster of heterogeneous disorders. To describe an innovative method to preserve fertility in young women with stage IA endometrial cancer with use of hysteroscopic resection followed by administration of 160 mg of megestrol acetate. aeruginosa strains showed high doubling time (26 h) due to competition from the accompanying flora.

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To evaluate the effects of cholesterol-lowering drugs including the inhibitors of cholesterol synthesis, atorvastatin and simvastatin, and the inhibitor of cholesterol absorption ezetimibe on NO release, NOS3 mRNA expression and miRs potentially involved in NO bioavailability. We describe the use of the Uro Dyna-CT, an imaging system used in the operating room that produces real-time three-dimensional (3D) imaging and cross-sectional image reconstructions similar to an intraoperative computerized tomography, during a percutaneous nephrolithotomy and a contralateral flexible ureteroscopy in a complete supine position.

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The detection of carotid plaque rupture caused by intraplaque hemorrhage by serial high-resolution magnetic resonance imaging: a case report. Should excised keloid scars be sent for routine histologic analysis?

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Heavy caseloads were perceived to result in a shift from proactive care towards reactive care, decreased quality of care and increased hospital admissions. The retrograde approach through epicardial collaterals (EC) for chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is a challenging procedure. Cholesterol and cell membrane function: a hypothesis concerning etiology of atherosclerosis.

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The median NT-proBNP plasma value for men and women in our cohort was calculated as 98 pg/ml, comparing favorably with reported values, in that a NT-proBNP concentration less than 100 pg/ml excludes acutely decompensated heart failure. Understanding the molecular mechanisms that control beta cell function and plasticity has critical implications for the pathophysiology and therapy of major forms of diabetes. Laboratory and some epidemiological studies suggest that antioxidants, such as vitamin C, are protective for cardiovascular disease. Claims data were used to calculate variables characterizing patients and their PCPs. High-dose atorvastatin in peripheral arterial disease (PAD): effect on endothelial function, intima-media-thickness and local progression of PAD.

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We aimed to determine the mechanisms underpinning glucocorticoid-induced insulin resistance in skeletal muscle and indentify how 11beta-HSD1 inhibitors improve insulin sensitivity. Possible higher valence states of cytochrome P-450 during oxidative reactions. The clear evolutionary relatedness of CBM20s to CBM21s, CBM48s and CBM53s suggests a common clan hosting most of the known SBDs.

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We hypothesized that CPA plays a mediating role in osteoblastic cells. Quantitative analysis of threshold limit levels of UV-irradiation in the workroom environment established in USA, Netherlands and Russia was made.

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Cell-penetrating peptides (CPPs), once postulated to cross cell membranes in a non-endocytic, non-energy-dependent process, have since been found to accumulate in vesicles in live mammalian cells. This molecular classification suggests the major birch pollen allergen, Bet v 1 as a marker for Fagales pollen and related plant food allergies, the major olive pollen allergen, Ole e 1, as a possible marker for Scrophulariales pollen allergy and the cedar allergens, Cry j 1 and Cry j 2, as potential markers for allergy to Coniferales pollens.

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Chloroquine treatment of infected mice caused a decrease in parasitaemia which was associated with restoration of indices altered during infection towards normalization. Our results suggest that p53 inactivation is associated with both BRCA1-associated and sporadic ovarian tumorigenesis, and that BRCA1-linked and sporadic ovarian cancers may develop through a similar carcinogenic pathway. Effect of ascorbic acid in vitro on lymphocyte reactivity to mitogens.

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Metastatic neuroendocrine tumors to the thyroid gland mimicking medullary carcinoma: a pathologic and immunohistochemical study of six cases. Only a few of these studies used appropriate analysis procedures to suit a Likert scale-type of answer or investigated large enough samples to ensure the stability of factorial solutions. Short-term changes in the firing pattern of hypothalamic neurons during Pavlovian conditioning. Obviating the need for a second incision at knee level, this technique offers a less invasive approach that should facilitate postoperative recovery and earlier discharge.

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BOS is a fibrosing process in the small airways causing irreversible airway obstruction. The presented case illustrate that the hepatitis C virus injures the transplanted liver by autoreinfection. Retrospective analysis of IPF patients comparing mean PAP at the time of initial evaluation for transplan- tation (mPAP(baseline)) with mPAP at the time of transplant (mPAP(follow-up)). In trying to reduce tremor output when the augmented feedback was provided novice subjects instead increased muscle activity which resulted in increased tremor.

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This study supports a role for the FcepsilonRI-beta gene in the expression of high affinity IgE receptor-mediated histamine release from basophils. Within this collection, some parameters showed strong correlation, indicating that a normal phenotype may be maintained by complementation among functional modules. The top 50 commercially successful films released per year from 1991 to 2000 were content coded to assess trends in tobacco use over time and attributes of films predictive of higher smoking rates.

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In systemic scleroderma, pulmonary abnormalities resulting in mild to moderate reduction in the diffusion capacity are associated with reduced ability of deep inspiration to reverse methacholine-induced early airway closure and bronchoconstriction. Particles were also consistently identified in the Golgi region.

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Computer simulation results for a class of chest X-ray images are presented. These include (i) the bulk transfer of energy through the intersubunit bridges from the large to the small subunit after peptidyltransfer, (ii) differences in the interaction of the sarcin ricin loop with the two elongation factors and (iii) networked information exchange pathways that may functionally facilitate intra- and intersubunit coordination, including the 5.8S rRNA. However, only an image on the focal plane is obtained by a single scan. Effects of a fall prevention program including exercise on mobility and falls in frail older people living in residential care facilities.

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Electroporation efficiency increases more steeply with power at low power values. Hospital-acquired infections following the 1999 Marmara earthquake. Cellular radioresistance was examined by a colony formation assay and Hoechst 33342 staining. Future studies should consider setting up multidisciplinary networks of medical professionals and communication experts, and holding training workshops to discuss the interpretation of results and risk communication. Sampling, testing and modeling particle size distribution in urban catch basins.

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These enabling excipients, which are produced on a large scale and incorporated into various marketed products worldwide, are now modified to render amphiphilic properties that enable them to be used to prepare nanoparticles. MAG is a safe and highly effective mobilization regimen in patients with lymphoma and acute leukemia.

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HCS is associated with mutations in exon 34 of NOTCH2 upstream the PEST domain that lead to the creation of a truncated and stable NOTCH2 protein with enhanced NOTCH2 signaling activity. Seventy-eight patients with curatively resected T3N0M0 stage sporadic colorectal cancer were accumulated. most midwives felt partner presence contributed to pain relief and were willing to allow partner presence as an intervention for childbirth pain. SIRT1 overexpression also activated the alpha-MHC gene promoter in transient transfection assays, thus confirming a role of SIRT1 in the induction of alpha-MHC expression.

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As to the mechanism, rapid endo- and exocytosis may take place in response to the amount of edema fluid in the surrounding extracellular space, where albumin may be eliminated through the transvascular route and/or via the cerebrospinal fluid space. However, the use of hormone replacement therapy for these conditions has given conflicting and disappointing results.

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Future research can address the reliability and validity of the NFOSI-18 in clinical research. Verification of a PCR-based typing method for Acinetobacter baumannii in a pseudo-outbreak investigation.

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This paper provides an overview of these risk factors, outlines how they individually and in interplay endanger favourable outcome by putting patients at risk for poor self-management. This is the basis of the proposed new method of focused impedance measurement (FIM). Candida endophthalmitis is a frequent complication of systemic candidiasis. Here, we show that the Prox1 transcription factor, which is expressed transiently and specifically in spinal interneurons, plays an important role in neurogenesis.

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Effect of carboplatin on the functional integrity of the human sperm membrane in vitro. Seventy-five percent of individuals who will not RTW by 2 years can be identified accurately at an early stage, using only these two predictors.

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The electroplating solution is a major source of wastewater in the printing wiring board industry. The technique is safe provided synchronization to the R wave is achieved. Health-related quality of life (HRQOL) is a marker of disease severity.

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We no longer use this protocol alone to treat delayed union after foot and ankle arthrodesis. Granulation, control of bacterial contamination, and enhanced lipid accumulation by driving nutrient starvation in coupled wastewater treatment and Chlorella regularis cultivation. Neither the clinical features nor the imaging techniques, including radiography, bone scintigraphy, computed tomography, and magnetic resonance imaging, were helpful in establishing the diagnosis.

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These findings suggested that infection of cattle with other genotypes was excluded. PC1, PC2, and PACE4 only produced N-terminal intermediates, but less efficiently than furin. Specific shRNAs were used to silence AEG-1 expression in HepG2 cells. Epithelioid sarcoma of vulva: a case report and review of the literature.

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This method does not require independence of observations, thus allowing for analysis of pedigree data as well, and allows adjustment for covariates. Subjects underwent standardized 75-gram oral glucose tolerance testing between the 24th and 28th weeks of their pregnancies. Whether the MMP-7 variant can be a new marker for liver cirrhosis will be further studied. The data on the organization and function of the photosystem I pigment-protein complexes of the cyanobacterium Spirulina and the characteristics of pigment antenna of the photosystem I monomeric and trimeric core complexes are presented and discussed.

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Regulation of the fibrinolytic potential of cultured human umbilical vein endothelial cells: astragaloside IV downregulates plasminogen activator inhibitor-1 and upregulates tissue-type plasminogen activator expression. Ectopic pregnancies occur because of conflicting signals to the blastocyst from the two epithelia (uterine and fallopian). In the absence of maternal GCs, there was a high percentage of DCs, many of them exhibiting a mature phenotype, in the 15-16 day-old Adx foetal thymus, which sharply decreased to reach control values on foetal day 17. The decrements in performance in the quadriceps muscle imply that full recovery (as defined by the preinjury state) is frequently not achieved and stress the need for accurate, objective assessment of muscle strength and further investigation into the nature and duration of rehabilitation after musculoskeletal injury.

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In man, cellular stratification was also lacking in the bow area. Control of calcium homeostasis by angiotensin II in adrenal glomerulosa cells through activation of p38 MAPK. The overall aim of this pilot trial is to assess the feasibility and preliminary efficacy of a DVD-based intervention for improving functional outcomes of survivors of stroke 2 months postrandomization to inform the design of a full-scale randomized clinical trial.

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All adolescent insurance members aged 12-18 years at first diagnosis of MDD. The relapse rates of beta-interferon users and nonusers were compared to ambient air inhalable particle levels and viral infections in the population with logistic regression. The effect of alcohol on CES1- and CES2-mediated probe drug hydrolysis was determined in vitro using recombinant human carboxylesterase. In this cycle, as determined using Metallosphaera sedula, malonyl-coenzyme A (malonyl-CoA) and succinyl-CoA are reductively converted via their semialdehydes to the corresponding alcohols 3-hydroxypropionate and 4-hydroxybutyrate.

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Taken together, our results suggest that ultraviolet-B-induced cell cycle arrest in A431 cells is mediated by cyclin-dependent kinase 4 downregulation. However, the molecular mechanisms by which autophagy regulates DNA damage repair remain largely elusive. To evaluate the permeability characteristics of the peritoneal membrane by measuring drained ultrafiltration volume relative to initial glucose concentration in dialysis fluid from the start to the end of continuous ambulatory peritoneal dialysis (CAPD) treatment in a selected cohort of patients with and without peritonitis.

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TSP-1 inhibits angiogenesis through direct effects on endothelial cell migration and survival and through indirect effects on growth factor mobilization. But other studies have indicated procoagulant functions for cathepsin G in activation of coagulation factor V or activation of platelets among other possible mechanisms.

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Moreover, phorbol esters were a much more potent inducer of collagenase-CAT gene transcription than insulin, a difference that may be explained by selective effects of insulin and phorbol esters on AP-1 expression. The induction of ornithine decarboxylase which was induced biphasically following partial hepatectomy was also reduced and delayed by 14-15 h by the administration of urethan. The wear of the ultra-high molecular weight polyethylene (UHMWPE) acetabular components and wear debris induced osteolysis are the major causes of failure in total hip replacements. In this modified chamber, shear flow can be introduced over the cell-substrate interface affecting tumor cell chemotactic migration through a microporous filter. Not only the numbers of genetic markers we are applying, but also the accurate phenotyping is critical in the success of setting-up a best-fitting model for prediction.

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The physiological conditions that lead to activation of these AT1 receptor-mediated inputs are unknown. A statewide screening, brief intervention, and referral to treatment (SBIRT) curriculum for medical residents: Differential implementation strategies in heterogeneous medical residency programs. These findings are discussed on the basis of gender-related research in general. The model of time-resolved transmittance is compared with experimental data acquired by use of a phantom consisting of wax fibers arranged within a solid cube of resin. Sympathetic neurons undergo apoptosis when deprived of nerve growth factor (NGF).

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Correlation between cholesterol esterification, MDR1 gene expression and rate of cell proliferation in CEM and MOLT4 cell lines. Randomised controlled trials (RCTs) or non-RCTs comparing oxygen versus no oxygen therapy or different methods of oxygen delivery in children with LRTI aged from three months to 15 years. A proper cast is essential for a successful rehabilitation with implant prostheses, in order to produce better structures and induce less strain on the implants. Since an incident ray experiences different variations of tilt angles with respect to bending direction, the blazed fiber Bragg grating has different coupling efficiencies of the first side mode, which can be reduced considerably in the case of twisted blazed fiber Bragg gratings. The half-life of progesterone receptor is extended in cells harboring mutations in BRCA1.

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Due to the photoisomerization of CNBE, the self-assembled nanostructures undergo morphological changes upon irradiation. revoluta (Arethuseae, Orchidaceae) has fern-type rheophyte characteristics in the leaves. These problems do not apply to pulses designed for high-speed gradient systems. Only patients with colorectal cancer as their first primary tumour and those born after 1920 were included. In this paper, the response of the Hindmarsh-Rose neuronal model to noisy signals is investigated and a variety of noise-induced resonances are described.