Bisocor is a medicine used to treat high blood pressure (hypertension) and heart failure.

If you have high blood pressure, taking Bisocor helps prevent future heart disease, heart attacks and strokes.

Bisocor is also used to prevent chest pain caused by angina.

It's also used to treat atrial fibrillation and other conditions that cause an irregular heartbeat.

This medicine is only available on prescription. It comes as tablets.

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Use of star volume to measure the size of the alveolar space in the asthmatic guinea-pig lung. Raloxifene has been shown to be beneficial using cardiovascular and osteoporosis end-points in studies of short duration. Neonatal asymmetric crying facies (NACF) is a specific phenotype, which is often underrecognized. Cancer cells in coculture with hepatocytes became rapidly activated with distinct morphological changes.

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Thirty of these patients (30 elbows) were located for extended follow-up. Expression and mutational analyses of KIT and PDGFR-alpha in sarcomatoid renal cell carcinoma. Evidence suggests that while the high prevalence of obstructive sleep apnea (OSA) in children with Down syndrome (DS) likely contributes to sleep fragmentation, their poor sleep is only partly attributable to the presence of OSA. Notably, CaSR-activated calcium transport is coupled to the presence of sufficient magnesium. We will successively review various therapeutic consensus, high risk factors, bordeline lesions and carcinomas in situ.

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Recently, it was shown that increased self-efficacy, decreased focusing on symptoms, increased physical functioning, and a change in beliefs about activity contribute to the decrease in fatigue. Instrumental studies in laboratories dedicated to the examination of disk overload in health workers Simultaneous amplification of multiple informative markers in conjunction with the mutation allows the building of familial haplotypes and accurate PGD analysis. The highly reproducible results of immunoaffinity HPMDC are compared with data obtained by widely used enzyme-linked immunosorbent assay. Treatment by combination of PTX and vitamin E appears to improve the pregnancy rate in patients with a thin endometrium by increasing the endometrial thickness and improving ovarian function.

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The vicissitudes of emergency psychiatry: a service systems perspective. Using event-related functional MRI, we were able to isolate temporally the neural correlates of processes contributing to the target presentation, delay, and probe portions of an item-recognition task. Native and gamma radiolysis-oxidized lipoprotein(a) increase the adhesiveness of rabbit aortic endothelium. Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase.

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Electron-dense cytoplasmic inclusions, termed viroplasms, function as sites of genome packaging and replication in the infected cell. Texture variations suppress suprathreshold brightness and colour variations.

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These findings indicate that a function of the Vsp-OspC family of proteins of Borrelia spp. Most of these emissions occurred between 1958 and 2002, followed by a substantial decrease.

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Study 2 tested a cognitive risk factors mediational model, and Study 3 tested an interpersonal stress generation mediational model. These phosphorylation events mediate the effects of Akt on cell survival, growth, differentiation, angiogenesis, migration and metabolism.

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The primary outcome was the between-group difference in AUDIT score at 2-3-month follow-up. Interestingly, Mfn2 is highly expressed in brown adipose tissue (BAT), yet its role remains unexplored. Metabolic encephalopathy may rarely produce oculomotor dysfunction, usually attributed to structural brainstem lesions. Genetic variants that predispose adults and the elderly to high blood pressure are largely unknown. Statistical analysis of latent generalized correlation matrix estimation in transelliptical distribution.

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The objective of the present study is to establish an optimal cutoff point for distress measured with the corresponding scale of the 4DSQ, using the prediction of sickness absence as a criterion. In order to identify strengths and gaps in the database for pyrethroid neurobehavioral toxicology, we have critically analyzed the data from peer-reviewed literature. Our results suggest a dramatic loss of CCR5 monotropism as dualtropism emerges in HIV-1C which has important implications for the use of coreceptor antagonists in therapeutic strategies for this subtype.

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Sustained viral suppression may result in regression of fibrosis, which in turn may lead to decreased disease-related morbidity and improved survival. Nevertheless, the prescription of massive quantities of immunoglobulins can lead to a drug shortage which the hospital pharmacist must deal with. Some BrdU-labelled T cells were observed in the longitudinal muscle but not in the myenteric ganglia. Adaptation of the endogenous Salmonella enterica serovar Typhi clyA-encoded hemolysin for antigen export enhances the immunogenicity of anthrax protective antigen domain 4 expressed by the attenuated live-vector vaccine strain CVD 908-htrA. Effect of heat stress on milk production, rectal temperature, respiratory rate and blood chemistry in Holstein, Jersey and Australian Milking Zebu cows.

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The purpose of this study is to summarize recent advances in the use of broadly neutralizing antibodies (bNAbs) as therapeutics in human clinical trials and in non-human primate (NHP) models. Strategic planning of statewide trauma systems can help balance rapid access to care with maintenance of adequate annual patient volumes of critically injured patients.

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HO-1 was also detected in macrophages/microglia within the infarct. Anesthetic and surgical techniques for the dog and cat are described.

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Cytochrome c (553, Chlorobium thiosulfatophilum) is a sulphide-cytochrome c reductase. Amniotic fluid samples from four fetuses with intestinal obstructions (two anal imperforations, one duodenal atresia and one multiple intestinal atresia) were deficient in disaccharidase activities.

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A 3-year-old Basiliscus plumifrons developed a necrotic lesion on the tail resulting from nodules of unknown etiology. Induction therapy was less used in patients with infection, which was related to prior VAD support. In conclusion both glycosylated and nonglycosylated G-CSF can be used effectively in treating AIN on a long-term basis.

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No association of clock gene T3111C polymorphism and affective disorders. Reactivation of chick erythrocyte nuclei in heterokaryons with rat hepatoma cells. Salmonella enterica isolates from faeces of domestic reptiles and a study of their antimicrobial in vitro sensitivity.

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ALK testing in lung adenocarcinoma: technical aspects to improve FISH evaluation in daily practice. No tests for oral manifestations have been validated for this pathology, and in the literature there are few studies of speech therapy for subjects with SSc. Currently evaluated strategies include the use of immunomodulatory factors, such as probiotics, prebiotics, and dietary nutrients, although data are still insufficient to make specific recommendations. Infrared spectroscopy of normal and abnormal cervical smears: evaluation by principal component analysis.

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Complex partial seizures present a major challenge for medical management. Depression and anxiety occur more frequently in cancer of the pancreas than they do in other forms of intra-abdominal malignancies and other cancers in general. Concepts concerning the evolutionary history of the GnRH system and its function in mammals, including humans, are likely to be modified as more complete sequence information becomes available.

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Gastroenteropathy is a major diabetic complication which may cause disturbed bowel motility leading to serious enterobacterial infections, thus, its amelioration is important. Examination of the pseudophase model of monomer-micelle interconversion in cetylpyridinium chloride. Controversy exists regarding the optimal way to provide health promotion education to the elderly.

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The prevalence of MS is more about high latitudes, and there is the same tendency in Japan. Endocrine cellular participation in the formation of lung tumors The dogs were euthanased 24 h post-injection along with one untreated unaffected and two MPS IIIA controls. Moreover, it should also be taken into account that the transdiphragmatic pressure increases in parallel with the growing intrathoracic pressure generated during obstructive apnea episodes.

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Sprague Dawley rats were cranial irradiated with electron beams delivered by a linear accelerator with a single dose of 20 Gy. The direct peroxide-peroxide fuel cells with a 10 cm3 min-1 flow rate display the open circuit voltage (OCV) of 0.85V and the peak power density of 56.5mWcm-2 at 155mAcm-2 with desirable cell stability, which is much higher than those previously reported. considered the relevant ones from immunohaematology, virology and clinical medicine so that their impact on the subject is taken into consideration. Analysis of xenograft mouse models confirmed FOXA1 loss in NEPC tumors relative to its adenocarcinoma counterparts. Recruitment in retractor bulbi muscle during eyeblink conditioning: EMG analysis and common-drive model.

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Subject to a few late changes, this version is due to take effect in March and will be used in fitness to practise cases from then on. Acidic isoferritin may turn to be a rather specific index of hepatic cancer. It is uncertain how PP2C isoforms are recruited, activated and inactivated during signalling transduction processes. Value of lifestyle intervention to prevent diabetes and sequelae. Egg-white antigens were identified in ingredients and in meat products with rabbit anti-egg-white antiserum by isoelectric focusing immunoblotting.

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The other two monoclonal anti-Nkx6-1 antibodies are specific to Nkx6-1 in mice but do not recognize Nkx6-1 in chicken and human. Identification and quantification of mixed sources of oil spills based on distributions and isotope profiles of long-chain n-alkanes. There is a specific portion of coronary artery aneurysm in Kawasaki disease. Well-defined treatment recommendations are still lacking, and it is unclear whether screening and treatment lead to improved outcome. Defective apoptotic mechanisms are considered to play a role in both the development of malignancy and resistance to chemotherapeutic drugs.

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The presence of laminated, calcified extracellular debris known as psammoma bodies is a well-known histomorphological feature of ovarian adenocarcinomas and other human malignancies. Caspases, a family of cysteine proteases, are at the heart of the apoptotic pathway. Our study is the first to provide a transcriptome sequence resource for H.

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Microangiography to Monitor Treatment Outcomes Following Severe Frostbite Injury to the Hands. A novel method has been developed for the detection of the mecA gene, that confers the principle mechanism of methicillin resistance in staphylococci. This finding, together with results from earlier studies, provides compelling evidence for the idea that p53 ablation is required for the development and maintenance of tumours.

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A retrospective analysis of 260 patients with the only diagnosis of endometriosis, or male factor, or tubal factor, or unexplained infertility were performed: a total of 56 patients with different stages of endometriosis, a control group consisting of 38 patients with male factor infertility, a group of 26 patients with tubal factor infertility and a group of 140 patients with others (unexplained infertility, ovulation disorders, cervical factor). Triglyceride storage in adipose tissue comprises the principal energy reserve in mammals.

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Transcription factors contributing to the pancreatic beta-cell phenotype. This CMR study provides further insights into the pathophysiological mechanisms in TTC, supporting the contribution of an inflammatory process in the acute setting.

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The 15N-labeling of the N3- ion obtained from all samples proved unequivocally that it came from the degradation of HN5 (tautomeric forms) and/or its anion N5- in the solution. A series of known and novel labeling reagents, all of which carry hydrazide functionality to allow glycan-specific derivatization, were prepared and evaluated in terms of their abilities to enhance the detection sensitivity of glycans, suppress ions of other contaminants (e.g., peptides), and detect acidic oligosaccharides. Next to TAG, LD also contain other neutral lipids such as diacylglycerol. The integrin alphavbeta6 promotes proliferation of specialized epithelia and acts as a receptor for the activation of latent TGFbeta1. We have shown that the transcription factor Sp1 is one of the regulators of ODC expression and that Sp3 antagonizes this Sp1-mediated activation of ODC expression.

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Turtles have a body plan unique among vertebrates in that their ribs have shifted topographically to a superficial layer of the body and the trunk muscles are greatly reduced. Current research is directed towards the prevention of the first stage in the pathogenesis of catheter-associated infections, namely the adherence of bacteria to the catheter polymer, e.g. The down-regulation of ER is one possible explanation for the repression of these immediate early genes during pregnancy.

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Hyaluronidase was measured in the H460M cell culture medium at the optimum pH 3.8, and was not found above pH 4.5, with the enzyme-linked sorbent assay technique and zymography. However, in MDA453 cells, posttranscriptional destabilization of AR mRNA appears to be the predominant mechanism resulting in down-regulation of AR mRNA by androgen. An amphibian CD3 homologue of the mammalian CD3 gamma and delta genes. Derivatives of VRSA were obtained by subculturing six VRSA colonies from the original culture with or without vancomycin.

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With the advance of previtellogenic growth the nurse cell cytoplasm is loaded with the growing number of ribosomes and contain perinuclear nuage material, mitochondria, electron dense bodies and aggregations of endoplasmic reticulum. The different areas and grade medicinal materials of Pseudostellariae Radix were respectively measured in quantitative characteristics of appearance, and the present grade classification of Pseudostellaria Radix was scientifically verified by the content of polysaccharide. Based upon these results, we were able to identify a 26-bp dyad symmetry element immediately upstream of the -35 regions of the predicted promoters of dprA, rec-2, and two other transformation genes, comA and pilA.

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Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation. The Hk(1)/Hk(2) heterozygote also responds to movements, establishing the allelism of the two mutants.-When Sh(5), a shaker mutant at another locus on the X chromosome, is introduced into the same chromosome as Hk(1) or Hk(2), the response is reduced in proportion to the number of Sh(5) mutant genes added.-When Hk(1) or Hk(2) is heterozygous with a deficiency for the hyperkinetic region of the X chromosome, the expression is more abnormal than the respective Hk(1) or Hk(2) homozygote. The ND results of proteins from this new method agree well with the results from an alternative well-established method, for the analysis of tetranitromethane (TNM)- and nitrogen dioxide and ozone (NO2/O3)-nitrated protein samples.

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Design Two-group randomized controlled trial recruiting primary care referrals to a borough-based exercise scheme. Comparative MD simulations combined with free energy calculations using the molecular mechanics-Poisson Boltzmann surface area (MM-PBSA) method show that large opposing energies are involved when forming the enzyme-substrate complexes. This indicates that the surface geology could be an important indicator for the As concentration in alluvial groundwater. The two-channel transmitter utilizes a miniature intrauterine pressure sensor which frequency modulates a subcarrier.

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Emerging experimental systems and increasingly specific analytical methods for the study of differences between normal and pre-eclamptic placentae are close to identifying specific indicators of disease, which may allow early diagnosis and intervention and reveal targets against which therapeutic agents can be developed. The cycloheximide-induced cessation of 38S RNA synthesis was accompanied by a marked increase in production of 12 to 15S and 28S RNA in L(1)VSV-infected cells, but no increase in synthesis of small RNA species occurred in S(2)VSV-infected cells.

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It is estimated, that in Poland around two million people suffer from COPD. The syntheses of these heterocycles are the first examples of Co(III)-catalyzed additions to aldehydes, and reactions are demonstrated for a variety of aromatic, heteroaromatic, and aliphatic derivatives. BxPC-3, MIA PaCa-2 and PANC-1 cells were cultured in the control, and in the ERS-mimicking diet culturing condition, to evaluate tumor growth and proliferation pathways.

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Cognitive skill learning: age-related differences in strategy shifts and speed of component operations. The MET signal, which is inhibited by crizotinib but not by alectinib, is dysregulated in many human cancers.

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We report a simple strategy for constructing silver coral-like nanostructures on graphite electrodes suitable for bioelectronic applications. These epithelial cell layers covered with methylcellulose solution were inoculated with H. They display homeotic transformations and malformations of cervical vertebrae and a retrolenticular membrane.

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All 7 informative and monoclonal cases of VIN with contiguous VSCC and 6/9 informative cases of VIN with noncontiguous VSCC showed patterns of X-chromosome inactivation consistent with a common monoclonal origin for both VIN and VSCC. Population prevalence of tilted optic disks and the relationship of this sign to refractive error.

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The subnanometer resolution structure of the glutamate synthase 1.2-MDa hexamer by cryoelectron microscopy and its oligomerization behavior in solution: functional implications. Predictive value of the C-reactive protein-to-prealbumin ratio in medical ICU patients. Off-pump coronary artery bypass surgery can be safely taught to cardiothoracic residents.