A 4-week, double-blind, parallel-group study to compare the gastrointestinal effects of Bioflac 7.5 mg, Bioflac 15 mg, piroxicam 20 mg and placebo by means of faecal blood loss, endoscopy and symptom evaluation in healthy volunteers. Systemic therapy with Bioflac can modify the progression of experimentally induced periodontitis in rats by reducing VEGF expression and alveolar bone loss.
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