Artane is used alone or together with other medicines (e.g., levodopa) to treat Parkinson's disease. By improving muscle control and reducing stiffness, this medicine allows more normal movements of the body as the disease symptoms are reduced.

Artane is also used to control severe muscle reactions and other side effects from certain medicines that are used to treat severe nausea or nervous, mental, or emotional conditions (e.g., haloperidol [Haldol], loxapine [Loxitane], prochlorperazine [Compazine], promethazine [Phenergan], thiothixene [Navane]).

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

• Elixir
• Tablet

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Effects of nordihydroguaiaretic acid on the growth and differentiation of SHG-44 glioma cell line Published data show that the risk is due either to a contaminant or to an added drug or falsification.

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Alterations in ultrastructural features of the lens fiber cells lead to scattering and opacity typical of cataracts. The emergency reporting system was set up in 14 counties hit hardest by the earthquake in Sichuan province, China. Dissections of regional lymph nodes for treatment of skin cancer: predicting annual caseloads that will optimise outcomes. Pre-operative staging of recto-sigmoid colon carcinoma by upper gastrointestinal endoscopic ultrasonography. As all sources of mechanical ventilation failed, extracorporeal membrane oxygenation had to be established 7 h after admission.

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OSAS may have a strong genetic basis due to the effects from a variety of genes including those for leptin receptor. The combination of doxorubicin (Dx) with paclitaxel or docetaxel is clinically effective but there are concerns regarding the higher incidence of cardiotoxicity of the combination compared with Dx alone. Aortic insufficiency is a valvular disease characterized by left ventricular volume overload. Student evaluations included positive responses to integrated instruction by both groups, though there was more trepidation expressed by some D/HH students. Although depression can be a serious consequence of concussion, little is known about the factors that predict depression and concussion recovery outcomes in children.

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Gastric cancer in patients with inflammatory bowel disease: more than just a random association? In this issue of the JCI, Popivanova and colleagues demonstrate that TNF-alpha, through its effects on the immune system, plays a critical role in promoting neoplastic transformation in this setting (see the related article beginning on page 560). We also concluded that clusterin expression may depend on the severity of the pathological keratinization. The degree of EH in the vestibule and cochlea was classified into three grades (none, mild, and significant). Atypical lentiginous junctional naevi of the elderly and melanoma.

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The effect of inhaled alpha particles (radon progeny) in rats was examined in the epithelial cells of the lateral well of the anterior nasal cavity. The brain, especially the hypothalamus, is strongly involved in regulating weight and food intake. However, the slow time course of the glucocorticoid effect suggests that trehalase may not be a primary response gene.

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The results obtained in this study suggest that circulating immune complexes in patients with SLE or in other conditions may suppress normal DNA clearance, and thereby contribute to the persistence of DNA in the circulation. Patients who had a persistently elevated ctDNA on therapy had a poor prognosis, and this may guide combination and sequencing of subsequent therapies. This approach may offer guidance to clinicians in distinguishing among the various causes of hospital-acquired thrombocytopenia and providing management appropriate to the etiology. Cisapride and caesarean section: their role in babies with gastroschisis.

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Although weight loss by dietary caloric energy restriction is successful in experimental studies, there is limited information on success of such programs in client-owned dogs who are obese. Standard use of praziquantel and corticosteroid drugs was applied, and the prognosis was good. ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing. Out of 368 patients admitted to hospital for chest pain and suspected acute myocardial infarction, 267 were discharged within 24 hours on the basis of the clinical picture, electrocardiogram, and serum activities of aspartate transaminase, alpha-hydroxybutyrate dehydrogenase, and creatine phosphokinase. There is a need for standardization of performance and interpretation of the spirometry test in Sweden and probably also in other countries.

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Computerized analysis of these radiographs provides a complete quantitative description of spinal configuration. These taxonomies went beyond evidence available on the structure of psychopathology and were shaped by a variety of other considerations, which may explain the aforementioned shortcomings. The finding that the waveform was sensitive even to the small atrial movements discernible during the rhythm of coarse atrial fibrillation was consistent with the possibility that blood flow within the vena cave-right atrial and/or the pulmonary venous-left atrial systems may be important in the genesis of the cardiac thoracic impedance waveform. Despite the existence and availability of effective and safe influenza vaccines, influenza still remains an important cause of morbidity and mortality worldwide, incl. Studies assessing the efficacy of azathioprine (AZA) in steroid-dependent ulcerative colitis (SD-UC) are scarce.

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Networks consisting of molecular wires alone were compared with networks containing voltage controlled molecular switches with two stable conductance states. Early surgery versus conventional treatment for asymptomatic severe aortic regurgitation with normal ejection fraction and left ventricular dilatation.

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MAP-2 is a sensitive and specific marker of neuroblastoma, both in the primary tumor and bone marrow biopsy settings. Sexual networks in Uganda: mixing patterns between a trading town, its rural hinterland and a nearby fishing village. From September 2005, a randomized Phase III clinical trial has been conducted to compare conventional (tangential field) fractionated whole breast treatment (Arm A) with accelerated partial breast irradiation plus intensity-modulated radiotherapy (Arm B). PRMT5 is a type II protein arginine methyltransferase with roles in stem cell biology, reprograming, cancer and neurogenesis.

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In our phase I dose-escalation study, maximum-tolerated dose (MTD) was not reached, and subsequently phase II study has been completed. Low serum zinc levels appear to be a consequence of insufficient nutrition, an observation which may indicate a correlation between nutritional deficiency and ulcer area. The study aimed to (1) discover the range of health-related topics that are addressed through Internet-delivered interventions, (2) generate a list of current websites used in the trials which demonstrate a health benefit, and (3) identify gaps in the research that may have hindered dissemination. A novel nano-micro structured octacalcium phosphate/protein composite coating on titanium by using an electrochemically induced deposition.

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The classical cortico-reticular theory on absence epilepsy suggests that a hyperexcitable cortex is a precondition for the occurrence of absence seizures. These oscillations are typically studied with regard to their amplitude, phase, and/or phase coupling.

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Seven consecutive patients who underwent posterior quadrant disconnection for refractory epilepsy were analyzed. The data support the original content of the classification as an aid to evaluation, prognosis, and treatment. The results provide a strong rationale for studying the in vivo effects of these compounds.

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The study population comprised 25,635 participants aged between 60 and 80 years at the time of examination from the Cohort of Norway (CONOR). Here, we report the X-ray structure of the FAD-containing Arabidopsis thaliana acyl-CoA oxidase 1 (ACX1), the first three-dimensional structure of a plant acyl-CoA oxidase. A novel continuous bioreactor system was developed as a shaken culture vessel for the investigation of the growth kinetics and product formation of microorganisms in milliscale. A case report of surgical correction for congenital mitral regurgitation with subvalvular apparatus abnormality.

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The manufacturer recommended depth of cure of bulk-fill resin-composites can be reached based on the microhardness method. The outcome of their treatment has been documented with lengthy otologic follow-up. blood pressure, heart weight, kidney weight and proteinuria relationships in NZB x OUW F1 hybrid female mice. Divergences in hydraulic architecture form an important basis for niche differentiation between diploid and polyploid Betula species in NE China.

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Systemic and Cerebral Concentration of Nimodipine During Established and Experimental Vasospasm Treatment. These results suggest that protein cage based nanoparticles may serve as safe, biocompatible, nanoplatforms for applications in medicine. Diabetes mellitus in coronary artery surgery: therapeutic strategies in the light of recent studies. Comment on: Comparison of serum sodium and potassium levels in patients with senile cataract and age-matched individuals without cataract. Prolonged hypoxia induces qualitative genetically fixed changes.

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The effect of clozapine on extracellular dopamine levels in the shell subregion of the rat nucleus accumbens is reversed following chronic administration: comparison with a selective 5-HT(2C) receptor antagonist. The time of the MRgFUS application after drug injection also proved to be an important factor with the best results observed when ultrasound was applied at least 6 h after the injection of drug-loaded nanodroplets.

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In this paper we suggest a new use for single heterostructure semiconductor lasers as a source of high power pulses of coherent light with halfwidths of the order of 10 psec, repetition rates up to hundreds of hertz and tunable photon energy output. To examine the characteristics of cases excluded from severe acute respiratory syndrome (SARS) and the reasons for exclusion.

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Preimplantation retrograde pneumoplegia in clinical lung transplantation. Optimisation of cultural conditions for antifungal antibiotic accumulation by Streptomyces rochei G164. Over a follow-up period extending to 18 months in one patient and 24 months in the other two, ultrasound imaging and arteriography have shown no restenosis at any treatment site. However, in ABA-inhibition of stomatal opening, an NO-dependent and an NO-independent pathway act: different signaling molecules participate in ABA-signaling cascade under different environmental condition. Furthermore, inhibition of adherence by WSF could be differentiated from its effects on chemotaxis in that reduced glutathione completely protected chemotaxis from the effects of WSF but only afforded partial protection to PMNL adherence.

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The aim of this study was to investigate whether MiR-30a regulates autophagy by regulating the Beclin-1 protein, which is the marker for autophagosomes during myocardial injury, when induced by angiotensin II (Ang II). Developing bactericidal coatings using simple green chemical methods could be a promising route to potential environmentally friendly applications. Ionizing radiation activates not only signalling pathways in the nucleus as a result of DNA damage, but also signalling pathways initiated at the level of the plasma membrane. To determine the clinical presentation, mode of investigation and management of gastric cancer at New Mulago Hospital. There are theoretical reasons for considering the possibility that the distribution of 45Ca between cytosol and membrane-associated sites could modulate some of the properties of the erythrocyte membrane.

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SIRS score of the patients who were treated with appendectomy was significantly higher than that of the patients treated with conservative therapy containing starvation and administration of antibiotics therapy and SIRS positive status in patients treated with appendectomy was also higher than that in patients with conservative therapy. It helps to increase the radioresistance and non- specific resistance of the organism under conditions of radioactive contamination of the environment. Mammography screening for women aged 40 through 49--a guidelines saga and a clarion call for informed decision making. Secondary complications (obstruction, urinary tract infections and pyelonephritis) must be avoided.

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A new type of the synapse interaction between excitatory and inhibitory fibres and the stretch receptor neuron dendrite has been described. It is concluded that, using the method adopted in this study, the mean interbeat interval can be regarded as the measure of choice for quantifying the post-caloric EOG response. Homologous recombination (HR) and nonhomologous end-joining (NHEJ) represent the two major pathways by which DSBs are repaired in mammalian cells.

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This study recommends that preconception BMI and total GWG be determined objectively and total GWG be adjusted for length of gestation before assessing adherence to the IOM GWG guidelines. It is not always easy to diagnose cystic tumours, including mucinous cystic tumours of the pancreas, and the final diagnosis is often reached only after the surgical procedure, which is the gold standard treatment of this disease. Serum estradiol-17beta and serum human chorionic gonadotropin in patients with hydatidiform moles. Haptoglobin, an acute phase protein, has four potential N-glycosylation sites, although it remains unknown which site is responsible for the change in fucosylated N-glycans.

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Morphologic characteristics of pulmonary macrophages in cetaceans: particular reference to pulmonary intravascular macrophages as a newly identified type. Such complications can occur before or after the first year post-PK.

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Telemedicine applications have been rapidly implemented since the early 1990s and are now in use in a wide range of healthcare settings. In gram-negative bacteria, the two-partner secretion (TPS) pathway is dedicated to the secretion of large proteins rich in beta-helical structure. However, the cluster coefficient is to be preferred if the interest is more aetiological, addressing for example why certain individuals are prone to multiple health problems. To establish the role of cancellous vertebral modulus on pedicle screw bending moments within the vertebral body and the vertebral pedicle.

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The substances were organized as liposomes and recombined with total human high density apolipoproteins and the two separated main components, apolipoprotein A-I (apoLp-Gln-I) and apolipoprotein A-II (apoLp-Gln-II). With all of these activities, the JUA hopes it will provide greater opportunities to young Japanese urologists to participate in educational projects in the US. Pancreatic stellate cells (PSC) are the main extracellular matrix-producing cell type in the diseased pancreas. In both vertebrates and invertebrates, secondary neurogenesis (including neuroblast proliferation and neuron differentiation) appears to be regulated by hormones, transmitters, growth factors and environmental cues. We sought to examine the association between first-pregnancy stillbirth and subsequent adverse perinatal outcomes.

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Transcatheter arterial embolization with polyvinyl alcohol particles combined with systemic medical treatment should be considered an efficacious and important therapeutic option for challenging cases. This study examined the dyadic patterns of IPV empirically and traced how these groups change over time. Sheep were sacrificed 4 to 12 months postoperatively and bladders were inspected for mucosal regrowth. Furthermore, the number of TH-positive cells in the MPO and caudal Arc was significantly decreased in 1yo ArKO compared to WT. In some such cases however, dirofilariasis correlated with the travel of the patient to the endemic areas.

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However, the change in the degree of scoliosis after pectus excavatum correction has not been clarified. Highly reversible capacity at the surface of a lithium-rich manganese oxide: a model study using an epitaxial film system. The collection of data regarding treatment utility involves the generation of large patient care databases which provide long-term data in representative, general practice, patient populations.

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Cataract is a very rare complication of burn injuries in which the eye is not directly marked. Lovastatin, mevastatin and simvastatin inhibited the growth, cell migration and invasion of HT144, M14 and SK-MEL-28 melanoma cells. Lactating and nulliparous outbred Swiss (CF-1 strain) mice were infected at 12-16 weeks of age with Nippostrongylus brasiliensis or Trichinella spiralis. The data were in agreement with previous studies showing that at the restrictive temperature this mutant is unable to alter its membrane fatty acid and phospholipid composition with temperature such that it is not able to maintain a membrane lipid composition which permits normal membrane function at the restrictive temperature. STAT3 phosphorylation was increased in pneumonic mouse lungs and in murine lung epithelial (MLE)-15 cells stimulated with pneumonic bronchoalveolar lavage fluid (BALF) through 48 hours of Escherichia coli pneumonia.

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Our results link visuospatial tuning effects of acetylcholine at the neuronal and perceptual levels and provide insights into the connection between cholinergic signaling and visual attention. A clinical trial of cyclophosphamide (NSC-26271) and radiation therapy for oat cell carcinoma of the lung. We show that whole Gram-positive bacteria, sPGN and LTA induce the activation of NF-kappaB in HEK293 cells expressing TLR2 but not in cells expressing TLR1 or TLR4.

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To explore the morbidity and risk factors of postoperative pancreatic fistula (POPF) following pancreaticoduodenectomy. Loneliness and social support in adolescent boys with autism spectrum disorders.

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These results indicate that Stat3 is constitutively activated in prostate cancer. Rather than attributing cognitive complaints in patients with ET to old age, assessment and possible treatment of dementia should be routinely incorporated into the treatment plan. Of the several ratios examined for consistency in differentiating cancer and normal tissues, the I(996 cm(-1))/I(966 cm(-1)) showed promise as a distinguishing parameter and was comparable to the I(1121 cm(-1))/I(1020 cm(-1)) ratio reported in many earlier studies.

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coli (EAEC) strain isolated from the stools of a diarrheic child. Various therapeutic strategies, including anti-tumor necrosis factor therapy, have been developed to target one or more of these factors.

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We used a microcarrier culture system and a combination of subtraction and reverse-subtraction methods to isolate a number of genes upregulated by shear stress. Further study revealed that the cell cycle arrest in the G1 phase by 25-methoxyhispidol A correlated well with the inhibition of phosphorylation of the retinoblastoma (Rb) protein, and with the down-regulation of cyclin D1 and cyclin-dependent kinase cdk4 and the induction of cdk inhibitor p21 (WAF1/Cip1) protein. Osteonecrosis in children treated for acute lymphoblastic leukemia: a magnetic resonance imaging study after treatment.